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Gene : Hmgcr D. melanogaster

DB identifier  ? FBgn0263782 Secondary Identifier  ? CG10367
Name  ? HMG Coenzyme A reductase Source  FlyBase
  • synonyms:
  • CG10367,
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase,
  • HMGCR,
  • FBgn0001205,
  • Hmg-CoA-reductase,
  • FBgn0263782,
  • FBgn0024247,
  • HMGCoAR,
  • BcDNA:LD15354,
  • HmG-CoAR,
  • Clb,
  • HMGCoARr,
  • hmgc,
  • unnamed,
  • l(3)04684,
  • FBgn0010845,
  • bs32f05.y1,
  • HMGCoA reductase,
  • DmHMG-CoAr,
  • FBan0010367,
  • l(3)01152,
  • bro1,
  • HMGCo-A reductase,
  • FBgn0010738,
  • FBgn0061415,
  • Hmg,
  • 3-Hydroxy-3-Methylglutaryl CoA Reductase,
  • HMG-CoA reductase,
  • lethal (3) 04684,
  • hmgrc,
  • columbus,
  • HMGCR_Dm

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29 Alleles

DB identifier Symbol Allele Class Organism
FBal0212247 Hmgcr[11.57]   Drosophila melanogaster
FBal0212248 Hmgcr[26.31]   Drosophila melanogaster
FBal0264323 Hmgcr[NIG.10367R]   Drosophila melanogaster
FBal0183297 Hmgcr[e02852]   Drosophila melanogaster
FBal0009515 Hmgcr[04684]   Drosophila melanogaster
FBal0160329 Hmgcr[EY04833]   Drosophila melanogaster
FBal0009402 Hmgcr[01152]   Drosophila melanogaster
FBal0249264 Hmgcr[MI02023]   Drosophila melanogaster
FBal0122098 Hmgcr[clb5]   Drosophila melanogaster
FBal0122103 Hmgcr[clb11]   Drosophila melanogaster
FBal0122101 Hmgcr[clb13]   Drosophila melanogaster
FBal0122095 Hmgcr[clb8]   Drosophila melanogaster
FBal0094692 Hmgcr[clb1]   Drosophila melanogaster
FBal0122100 Hmgcr[clb3]   Drosophila melanogaster
FBal0086686 Hmgcr[unspecified]   Drosophila melanogaster
FBal0122094 Hmgcr[clb9]   Drosophila melanogaster
FBal0094691 Hmgcr[clb2]   Drosophila melanogaster
FBal0122097 Hmgcr[clb6]   Drosophila melanogaster
FBal0098376 Hmgcr[C14.5]   Drosophila melanogaster
FBal0122104 Hmgcr[clb10]   Drosophila melanogaster
FBal0122102 Hmgcr[clb12]   Drosophila melanogaster
FBal0122096 Hmgcr[clb7]   Drosophila melanogaster
FBal0122099 Hmgcr[clb4]   Drosophila melanogaster
FBal0094693 Hmgcr[Scer\UAS.cvDa]   Drosophila melanogaster
FBal0193277 Hmgcr[dsRNA.cYa]   Drosophila melanogaster
FBal0193278 Hmgcr[Act5C.T:SV5\V5]   Drosophila melanogaster
FBal0214554 Hmgcr[GD212]   Drosophila melanogaster
FBal0098029 Hmgcr[C14.4]   Drosophila melanogaster
FBal0231489 Hmgcr[KK101807]   Drosophila melanogaster

54 Clones

Secondary Identifier DB identifier
AT26695 FBcl0004841
AT10309 FBcl0004849
AT09882 FBcl0004857
AT21927 FBcl0004865
AT26604 FBcl0004873
AT21903 FBcl0004881
AT28982 FBcl0004897
AT09917 FBcl0004905
AT08550 FBcl0004913
AT02128 FBcl0004929
bs20d07 FBcl0048031
bs66h04 FBcl0048053
bs32f05 FBcl0048055
EK243128 FBcl0123180
EK191960 FBcl0123186
EK023559 FBcl0123192
EK243134 FBcl0123322
EK218737 FBcl0123334
EK234530 FBcl0123346
EK243131 FBcl0123354
EK146955 FBcl0123414
LD15354 FBcl0156884
RH70236 FBcl0258964
EC051259 FBcl0300205
EC056259 FBcl0300206
EC054254 FBcl0300207
EC052262 FBcl0300208
EC052256 FBcl0300209
Dmel_neb_014522_0201_0517 FBcl0370343
CK01.27A.G6 FBcl0416213

6 Exons

DB identifier Symbol
FBgn0263782:5 Hmgcr:5
FBgn0263782:6 Hmgcr:6
FBgn0263782:1 Hmgcr:1
FBgn0263782:2 Hmgcr:2
FBgn0263782:3 Hmgcr:3
FBgn0263782:4 Hmgcr:4

1 Transcripts

DB identifier Gene
FBtr0084450 Hmgcr

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0084450-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084450-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42803 NCBI Entrez Gene identifiers FBgn0263782
67741 BioGRID FBgn0263782

9 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

5 Introns

DB identifier
Organism . Name
intron_FBgn0263782:1_FBgn0263782:2 Drosophila melanogaster
intron_FBgn0263782:2_FBgn0263782:3 Drosophila melanogaster
intron_FBgn0263782:3_FBgn0263782:4 Drosophila melanogaster
intron_FBgn0263782:4_FBgn0263782:5 Drosophila melanogaster
intron_FBgn0263782:5_FBgn0263782:6 Drosophila melanogaster

19 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Hmgcr none 1.230681052   19067489
Lipid storage Hmgcr none 0.226723453   19067489
ERK signaling Hmgcr ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Hmgcr Decreased GFP protein expression moderate   16020693
Mycobacterial infection (1) - M. fortuitum infection Hmgcr Decreased M. fortuitum intracellular infection 8.1 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis Hmgcr Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) Hmgcr Decreased horseradish peroxidase protein expression sp   16452979
Brucella melitensis infection Hmgcr Decreased Brucella melitensis infection 12.83   18654626
Influenza replication Hmgcr Decreased Influenza replication -3.08/-0.36   18615016
Mutant human huntingtin aggregation Hmgcr Decreased mutant human huntingtin aggregation <= -2   19789644
S2 cell spreading Hmgcr none np   21041442
RTK-Ras-ERK pathway regulation (1) Hmgcr Decreased ERK phosphorylation after EGF stimulation -1.79 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Hmgcr Decreased ERK phosphorylation after EGF stimulation -3.19 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Hmgcr none -0.29 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Hmgcr Decreased ERK phosphorylation after sSpitz and EGF stimulation -1.99 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Hmgcr none -0.79   23263283
Glycosylation regulation (1) Hmgcr Decreased alpha1,3-fucose Chp glycosylation, decreased alpha1,6-fucose Chp glycosylation, decreased mannose Chp glycosylation sp   21203496
Glycosylation regulation (2) Hmgcr none np   21203496
Huntingtin (Htt) aggregates formation Hmgcr Decreased formation of mutant Huntingtin (Httex1-Qn) protein aggregates np   20100940

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