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Gene : smo D. melanogaster

DB identifier  ? FBgn0003444 Secondary Identifier  ? CG11561
Name  ? smoothened Source  FlyBase
  • synonyms:
  • FBan0011561,
  • SMO,
  • CG11561,
  • Smoothened,
  • Smoothene,
  • FBgn0003444,
  • smooth,
  • dSmo

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258 Alleles

DB identifier Symbol Allele Class Organism
FBal0198033 smo[tTW116]   Drosophila melanogaster
FBal0270030 smo[Scer\UAS.cCa.T:Hsap\MYC]   Drosophila melanogaster
FBal0270031 smo[C320A.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0270032 smo[C339A.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0270033 smo[C413A.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0220727 smo[JF02363]   Drosophila melanogaster
FBal0284540 smo[Scer\UAS.cHa]   Drosophila melanogaster
FBal0284541 smo[S670L.Scer\UAS]   Drosophila melanogaster
FBal0284542 smo[act.Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0284543 smo[EW2]   Drosophila melanogaster
FBal0281178 smo[GL01472]   Drosophila melanogaster
FBal0216240 smo[RA3.Scer\UAS]   Drosophila melanogaster
FBal0216238 smo[Scer\UAS.cZa]   Drosophila melanogaster
FBal0216241 smo[RA12.Scer\UAS]   Drosophila melanogaster
FBal0216243 smo[RA14.Scer\UAS]   Drosophila melanogaster
FBal0216239 smo[RA1.Scer\UAS]   Drosophila melanogaster
FBal0216242 smo[RA13.Scer\UAS]   Drosophila melanogaster
FBal0216244 smo[RA123.Scer\UAS]   Drosophila melanogaster
FBal0216247 smo[RA12K34.Scer\UAS]   Drosophila melanogaster
FBal0216245 smo[RA124.Scer\UAS]   Drosophila melanogaster
FBal0216246 smo[RA1234.Scer\UAS]   Drosophila melanogaster
FBal0216252 smo[N.Scer\UAS.T:Avic\GFP-CFP]   Drosophila melanogaster
FBal0216249 smo[SMOEDS.Scer\UAS]   Drosophila melanogaster
FBal0216250 smo[Delta661-818.Scer\UAS.T:Avic\GFP-CFP]   Drosophila melanogaster
FBal0216251 smo[AN1234.Scer\UAS]   Drosophila melanogaster
FBal0216253 smo[N.Scer\UAS.T:Avic\GFP-YFP]   Drosophila melanogaster
FBal0216254 smo[C.Scer\UAS.T:Avic\GFP-YFP]   Drosophila melanogaster
FBal0216248 smo[RA12D3.Scer\UAS]   Drosophila melanogaster
FBal0175474 smo[C.Scer\UAS.T:Avic\GFP-CFP]   Drosophila melanogaster
FBal0216255 smo[L3C.Scer\UAS.T:Avic\GFP-CFP,T:Avic\GFP-YFP]   Drosophila melanogaster

37 Clones

Secondary Identifier DB identifier
FI05257 FBcl0481811
bs82f03 FBcl0056577
EC32237 FBcl0061307
EP17917 FBcl0074453
EK009122 FBcl0075830
EK115607 FBcl0076046
EK071840 FBcl0076072
EK092635 FBcl0076126
EK219014 FBcl0076166
EK108307 FBcl0076204
EK107707 FBcl0076216
EK046743 FBcl0076226
EK208638 FBcl0076238
EK163164 FBcl0076248
EK129714 FBcl0076270
EK258739 FBcl0076280
EK093639 FBcl0076310
LD13873 FBcl0156340
LD34308 FBcl0169954
RE02201 FBcl0212797
RE51422 FBcl0212896
RE19093 FBcl0213011
RE29651 FBcl0213074
RE16641 FBcl0213076
RE41106 FBcl0213097
RE27868 FBcl0213106
RE37062 FBcl0213108
RE48622 FBcl0213133
RE71732 FBcl0213156
RE26554 FBcl0213182

6 Exons

DB identifier Symbol
FBgn0003444:2 smo:2
FBgn0003444:3 smo:3
FBgn0003444:4 smo:4
FBgn0003444:5 smo:5
FBgn0003444:6 smo:6
FBgn0003444:1 smo:1

1 Transcripts

DB identifier Gene
FBtr0078129 smo

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0078129-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078129-3-prime-utr Drosophila melanogaster

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3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
33196 NCBI Entrez Gene identifiers FBgn0003444
33195 NCBI Entrez Gene identifiers FBgn0003444
59452 BioGRID FBgn0003444

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 280.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 279.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 302.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 432.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 535.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 249.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 195.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 370.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 215.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 301.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 400.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 396.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 499.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 544.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 536.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 471.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 443.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 709.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 379.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 483.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 460.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 420.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 322.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 453.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 382.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1146.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2042.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 978.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 567.0
FBgn0003444 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 686.0

5 Introns

DB identifier
Organism . Name
intron_FBgn0003444:1_FBgn0003444:2 Drosophila melanogaster
intron_FBgn0003444:2_FBgn0003444:3 Drosophila melanogaster
intron_FBgn0003444:3_FBgn0003444:4 Drosophila melanogaster
intron_FBgn0003444:4_FBgn0003444:5 Drosophila melanogaster
intron_FBgn0003444:5_FBgn0003444:6 Drosophila melanogaster

16 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage smo none 0.041007534   19067489
Lipid storage smo none 1.437484771   19067489
Hedgehog signaling smo Decreased Hedgehog reporter activity np   12663920
Hedgehog signaling smo Decreased Hedgehog reporter activity -5.16   16311596
Cell size and cell-cycle regulation (1) smo none sp   16496002
Embryonic nervous system development smo Loss of commissures; disruption of longitudinal connectives in ventral nerve cord; loss of cells and disorganization of peripheral nervous system np   15534205
Heart development and function smo Cardiac precursors specification defects np   14684833
Muscle morphogenesis and function (1) smo Wing posture defect np   20220848
Heat nociception (1) smo none -0.02   21074052
Heart development and function (1) smo none 1   20371351
Notch pathway regulation (4) smo Notum malformation migration 2   19363474
Hh pathway regulation smo Downregulation of Hh pathway -0.843197192233104   17903264
Hh pathway regulation smo Downregulation of Hh pathway -0.816576717658675   17903264
Hippo pathway regulation smo none -0.88   23263283
Glycosylation regulation (1) smo Decreased GlcNAcb1-4GlcNAc Chp glycosylation sp   21203496
Glycosylation regulation (2) smo none np   21203496

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