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Gene : Lrrk D. melanogaster

DB identifier  ? FBgn0038816 Secondary Identifier  ? CG5483
Name  ? Leucine-rich repeat kinase Source  FlyBase
  • synonyms:
  • FBan0005483,
  • FBgn0038816,
  • LRRK2,
  • dLRRK,
  • CG5483,
  • LRRK,
  • CT17358

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23 Alleles

DB identifier Symbol Allele Class Organism
FBal0209950 Lrrk[GD11670]   Drosophila melanogaster
FBal0282481 Lrrk[G1914S.Scer\UAS]   Drosophila melanogaster
FBal0220786 Lrrk[Scer\UAS.cIa]   Drosophila melanogaster
FBal0220787 Lrrk[Y1383C.Scer\UAS]   Drosophila melanogaster
FBal0220788 Lrrk[I1915T.Scer\UAS]   Drosophila melanogaster
FBal0220789 Lrrk[unspecified]   Drosophila melanogaster
FBal0220791 Lrrk[dsRNA.Scer\UAS.cIa]   Drosophila melanogaster
FBal0220790 Lrrk[3KD.Scer\UAS]   Drosophila melanogaster
FBal0246344 Lrrk[WT.Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0246345 Lrrk[RC.Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0246346 Lrrk[ex1]   Drosophila melanogaster
FBal0246347 Lrrk[G7459]   Drosophila melanogaster
FBal0282479 Lrrk[Scer\UAS.cDa]   Drosophila melanogaster
FBal0282480 Lrrk[T:Hsap\MYC]   Drosophila melanogaster
FBal0285575 Lrrk[EX2]   Drosophila melanogaster
FBal0284311 Lrrk[Scer\UAS.cLa]   Drosophila melanogaster
FBal0185431 Lrrk[e03680] amorphic allele - molecular evidence Drosophila melanogaster
FBal0249348 Lrrk[R1069G.Scer\UAS]   Drosophila melanogaster
FBal0262616 Lrrk[GL00136]   Drosophila melanogaster
FBal0279051 Lrrk[HMS01937]   Drosophila melanogaster
FBal0248212 Lrrk[HMS00456]   Drosophila melanogaster
FBal0230990 Lrrk[KK100916]   Drosophila melanogaster
FBal0274700 Lrrk[NIG.5483R]   Drosophila melanogaster

24 Clones

Secondary Identifier DB identifier
EK198027 FBcl0074408
EK218016 FBcl0074528
EK305527 FBcl0074696
EK257742 FBcl0075680
EK108354 FBcl0075740
EK176863 FBcl0075806
EK217532 FBcl0076004
EP16937 FBcl0089651
EC052869 FBcl0300079
EC053512 FBcl0300080
EC054009 FBcl0300081
EC054526 FBcl0300082
EC055978 FBcl0300083
EC054787 FBcl0300084
EC053770 FBcl0300085
EC053356 FBcl0300086
Dmel_dig_011874_0715_0676 FBcl0369859
9368 FBcl0470102
153772 FBcl0471721
83633 FBcl0473252
84051 FBcl0473494
280766 FBcl0473518
108551 FBcl0473500
70415 FBcl0473533

13 Exons

DB identifier Symbol
FBgn0038816:3 Lrrk:3
FBgn0038816:4 Lrrk:4
FBgn0038816:5 Lrrk:5
FBgn0038816:6 Lrrk:6
FBgn0038816:7 Lrrk:7
FBgn0038816:8 Lrrk:8
FBgn0038816:9 Lrrk:9
FBgn0038816:10 Lrrk:10
FBgn0038816:11 Lrrk:11
FBgn0038816:12 Lrrk:12
FBgn0038816:13 Lrrk:13
FBgn0038816:1 Lrrk:1
FBgn0038816:2 Lrrk:2

3 Transcripts

DB identifier Gene
FBtr0112788 Lrrk
FBtr0334640 Lrrk
FBtr0334641 Lrrk

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0112788-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334640-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334641-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0112788-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334640-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334641-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42447 NCBI Entrez Gene identifiers FBgn0038816
67423 BioGRID FBgn0038816

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 213.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 211.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 224.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 269.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 431.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 176.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 226.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 332.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 171.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 315.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 246.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 238.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 189.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 248.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 251.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 290.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 308.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 283.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 222.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 231.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 380.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 218.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 312.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 228.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 364.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 735.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 598.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 518.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 279.0
FBgn0038816 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 316.0

13 Introns

DB identifier
Organism . Name
intron_FBgn0038816:3_FBgn0038816:4 Drosophila melanogaster
intron_FBgn0038816:4_FBgn0038816:5 Drosophila melanogaster
intron_FBgn0038816:5_FBgn0038816:6 Drosophila melanogaster
intron_FBgn0038816:6_FBgn0038816:7 Drosophila melanogaster
intron_FBgn0038816:7_FBgn0038816:8 Drosophila melanogaster
intron_FBgn0038816:8_FBgn0038816:9 Drosophila melanogaster
intron_FBgn0038816:9_FBgn0038816:10 Drosophila melanogaster
intron_FBgn0038816:10_FBgn0038816:11 Drosophila melanogaster
intron_FBgn0038816:11_FBgn0038816:12 Drosophila melanogaster
intron_FBgn0038816:12_FBgn0038816:13 Drosophila melanogaster
intron_FBgn0038816:1_FBgn0038816:4 Drosophila melanogaster
intron_FBgn0038816:1_FBgn0038816:2 Drosophila melanogaster
intron_FBgn0038816:2_FBgn0038816:4 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Lrrk none 0   19067489
Lipid storage Lrrk none 1.243790585   19067489
Lipid storage Lrrk none 0.274581216   19067489
Lipid storage Lrrk none -0.381686357   19067489
Lipid storage Lrrk none 1.670405003   19067489
Lipid storage Lrrk none 0.031577469   19067489
Cell cycle regulation (1) Lrrk Decreased number of cells in prometaphase and metaphase, centrosome defects sp   15616552
Cell cycle regulation (2) Lrrk none np   15616552
NFAT signaling Lrrk Decreased NFAT translocation 1   16511445
Muscle morphogenesis and function (1) Lrrk none np   20220848
Muscle morphogenesis and function (1) Lrrk none np   20220848
Heat nociception (1) Lrrk none -1.17   21074052
Heat nociception (1) Lrrk none -1.17   21074052
Heart development and function (1) Lrrk none 1   20371351
Heart development and function (2) Lrrk none 2.44   20371351
Serratia marcescens infection (1) Lrrk none -1.23   19520911
Notch pathway regulation (4) Lrrk none 0   19363474
Notch pathway regulation (4) Lrrk none 0   19363474
Adiposity regulation (1) Lrrk none -0.066   20074523
Blood cell homeostasis regulation (1) Lrrk none np   20540764
Blood cell homeostasis regulation (2) Lrrk none np   20540764
Actin organization and cell morphology (1) Lrrk none np   19265526
Actin organization and cell morphology (2) Lrrk none np   19265526
Actin organization and cell morphology (3) Lrrk none np   19265526
Actin organization and cell morphology (4) Lrrk none np   19265526
Actin organization and cell morphology (5) Lrrk none np   19265526
Actin organization and cell morphology (6) Lrrk none np   19265526
Vaccinia virus infection Lrrk none sp   20585561
Hippo pathway regulation Lrrk none 0.08   23263283
Glycosylation regulation (1) Lrrk none sp   21203496

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