Genomics
Gene Ontology Displayer
Homologue Displayer
Mod Mine G Browse Displayer
Overlapping Features Displayer
Regulatory Regions Displayer
13 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0263548 | Cdk8[Ubi-p63E.PL] | Drosophila melanogaster | |
| FBal0283016 | Cdk8[c01804] | Drosophila melanogaster | |
| FBal0242962 | Cdk8[H2480] | Drosophila melanogaster | |
| FBal0242963 | Cdk8[GMR.PB] | Drosophila melanogaster | |
| FBal0282538 | Cdk8[dsRNA.Scer\UAS] | Drosophila melanogaster | |
| FBal0160706 | Cdk8[A162] | Drosophila melanogaster | |
| FBal0286520 | Cdk8[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0286521 | Cdk8[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0270518 | Cdk8[NIG.10572R] | Drosophila melanogaster | |
| FBal0262702 | Cdk8[GL00231] | Drosophila melanogaster | |
| FBal0218350 | Cdk8[K185] | amorphic allele - molecular evidence, amorphic allele - genetic evidence | Drosophila melanogaster |
| FBal0206545 | Cdk8[GD7022] | Drosophila melanogaster | |
| FBal0235129 | Cdk8[KK107735] | Drosophila melanogaster |
7 Clones
| Secondary Identifier | DB identifier |
|---|---|
| RE13344 | FBcl0210991 |
| RM06792 | FBcl0381820 |
| RM07192 | FBcl0381821 |
| RM06692 | FBcl0381822 |
| RM06992 | FBcl0381823 |
| RM07292 | FBcl0381824 |
| FI03233 | FBcl0718770 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0076369-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0076369-3-prime-utr | Drosophila melanogaster |
Other
35 Pathways
- Signaling by NOTCH,
- Gene Expression,
- Signaling by NODAL,
- Loss of Function of TGFBR1 in Cancer,
- Signaling by NOTCH1 PEST Domain Mutants in Cancer,
- Generic Transcription Pathway,
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer,
- TGF-beta receptor signaling activates SMADs,
- Transcriptional Regulation of White Adipocyte Differentiation,
- Signaling Pathways,
- Loss of Function of TGFBR2 in Cancer,
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,
- Signaling by NOTCH1,
- SMAD2/3 MH2 Domain Mutants in Cancer,
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer,
- SMAD2/3 Phosphorylation Motif Mutants in Cancer,
- TGFBR1 KD Mutants in Cancer,
- Disease,
- Signaling by NOTCH1 in Cancer,
- Signaling by TGF-beta Receptor Complex in Cancer,
- NOTCH1 Intracellular Domain Regulates Transcription,
- Signaling by NOTCH1 HD Domain Mutants in Cancer,
- Constitutive Signaling by NOTCH1 PEST Domain Mutants,
- Loss of Function of SMAD2/3 in Cancer,
- Signaling by Activin,
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription,
- Signaling by TGF-beta Receptor Complex,
- TGFBR2 MSI Frameshift Mutants in Cancer,
- FBXW7 Mutants and NOTCH1 in Cancer,
- TGFBR2 Kinase Domain Mutants in Cancer,
- TGFBR1 LBD Mutants in Cancer,
- Developmental Biology,
- Loss of Function of SMAD4 in Cancer,
- SMAD4 MH2 Domain Mutants in Cancer,
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 39157 | NCBI Entrez Gene identifiers | FBgn0015618 |
| 64544 | BioGRID | FBgn0015618 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
45 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Cdk8 | none | 0.079622947 | 19067489 | |
| Lipid storage | Cdk8 | none | -0.106746601 | 19067489 | |
| Cell morphology | Cdk8 | Morphology | np | 14527345 | |
| Cell cycle regulation (1) | Cdk8 | Increased S DNA content, equal G1 and G2/M DNA content | sp | 15616552 | |
| Cell cycle regulation (2) | Cdk8 | Increased S DNA content or increased number of aneuploid cells, decreased G2 DNA content | np | 15616552 | |
| Cell size and cell-cycle regulation (1) | Cdk8 | Increased G1 DNA content, decreased G2 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Cdk8 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Cdk8 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Cdk8 | none | 0.95 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Cdk8 | none | 456 | 16496002 | |
| Dendrite pattern formation | Cdk8 | none | np | 16547170 | |
| Muscle morphogenesis and function (1) | Cdk8 | none | np | 20220848 | |
| Muscle morphogenesis and function (1) | Cdk8 | none | np | 20220848 | |
| Heat nociception (1) | Cdk8 | none | -0.1 | 21074052 | |
| Heart development and function (1) | Cdk8 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Cdk8 | none | 0.528571428571428 | 19520911 | |
| Notch pathway regulation (4) | Cdk8 | Notum malformation migration, overproliferation | sp | 19363474 | |
| Notch pathway regulation (4) | Cdk8 | Notum malformation migration, overproliferation | sp | 19363474 | |
| Notch pathway regulation (4) | Cdk8 | Loss of bristles, notum malformation migration, overproliferation | sp | 19363474 | |
| Notch induced transcription | Cdk8 | none | -0.63955 | N(delta)ecn Notch stimulation | 20959007 |
| Notch induced transcription | Cdk8 | none | -0.7551 | without Notch stimulation | 20959007 |
| Notch induced transcription | Cdk8 | Downregulation of Notch pathway after Notch stimulation | -2.1741 | N(delta)ecn Notch stimulation | 20959007 |
| G2-M DNA damage checkpoint regulation (2) | Cdk8 | Increased histone H3 phosphorylation with bleocin | 59.14 | with bleocin | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | Cdk8 | Increased histone H3 phosphorylation with doxorubicin | 58.87 | with doxorubicin | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | Cdk8 | Increased histone H3 phosphorylation with etoposide | 43.77 | with etoposide | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | Cdk8 | Increased histone H3 phosphorylation after X-ray exposure | 60.28 | X-ray exposure | 21205937 |
| Pol II elongation | Cdk8 | Decreased Hsp70 mRNA expression | 60 | 20 min heat shock | 19279664 |
| Pol II elongation | Cdk8 | Decreased Hsp70 mRNA expression | 60 | 20 min heat shock | 19279664 |
| Adiposity regulation (1) | Cdk8 | none | -1 | 20074523 | |
| Blood cell homeostasis regulation (1) | Cdk8 | none | np | 20540764 |
