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Gene : 14-3-3epsilon D. melanogaster

DB identifier  ? FBgn0020238 Secondary Identifier  ? CG31196
Name  ? 14-3-3epsilon Source  FlyBase
  • synonyms:
  • anon-WO02059370.52,
  • FBgn0051196,
  • D14-3-3e,
  • FBgn0016743,
  • anon-WO0172774.141,
  • 14-3-3EPSILON,
  • eps,
  • PAR-5,
  • 14-3-3 epsilon,
  • 14.3.3 epsilon,
  • SR3-9,
  • Epsilon,
  • EK3-5,
  • Tyrosine-3-monooxygenase,
  • 14-3-3omicron,
  • FBgn0064146,
  • CG31196,
  • 14-3-3-e,
  • Suppressor of Ras85D 3-9,
  • FBan0031196,
  • 14-3-3-epsilon,
  • 14-3-3,
  • FBgn0011329,
  • PAR5,
  • 14-3-3e,
  • FBgn0046456,
  • l(3)j2B10,
  • Su(Raf)3B,
  • 14-3-30epsilon,
  • 14-3-3&epsilon,
  • 1433epsilon,
  • D14-3-3epsilon,
  • FBgn0020238,
  • FBgn0016739,
  • FBgn0066007,
  • CT24092,
  • 143E_DROME

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42 Alleles

DB identifier Symbol Allele Class Organism
FBal0277318 14-3-3epsilon[Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0285954 14-3-3epsilon[G00082]   Drosophila melanogaster
FBal0270081 14-3-3epsilon[dsRNA.Scer\UAS.cTa]   Drosophila melanogaster
FBal0244973 14-3-3epsilon[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0244974 14-3-3epsilon[Scer\UAS.T:Ivir\HA1]   Drosophila melanogaster
FBal0220285 14-3-3epsilon[EP3-732]   Drosophila melanogaster
FBal0211603 14-3-3epsilon[CA06506]   Drosophila melanogaster
FBal0245304 14-3-3epsilon[HM04001]   Drosophila melanogaster
FBal0188364 14-3-3epsilon[c06714]   Drosophila melanogaster
FBal0188361 14-3-3epsilon[f05080]   Drosophila melanogaster
FBal0188362 14-3-3epsilon[e03838]   Drosophila melanogaster
FBal0188363 14-3-3epsilon[e00326]   Drosophila melanogaster
FBal0188365 14-3-3epsilon[c06705]   Drosophila melanogaster
FBal0148516 14-3-3epsilon[PL00784]   Drosophila melanogaster
FBal0157549 14-3-3epsilon[EP3423]   Drosophila melanogaster
FBal0010913 14-3-3epsilon[j2B10] loss of function allele Drosophila melanogaster
FBal0157548 14-3-3epsilon[EP3578]   Drosophila melanogaster
FBal0049166 14-3-3epsilon[18A2] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0122336 14-3-3epsilon[Delta24]   Drosophila melanogaster
FBal0148514 14-3-3epsilon[ex4]   Drosophila melanogaster
FBal0048993 14-3-3epsilon[S-1259]   Drosophila melanogaster
FBal0121020 14-3-3epsilon[unspecified]   Drosophila melanogaster
FBal0048994 14-3-3epsilon[S-696] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0262832 14-3-3epsilon[GL00366]   Drosophila melanogaster
FBal0261356 14-3-3epsilon[CPTI100034]   Drosophila melanogaster
FBal0261357 14-3-3epsilon[CPTI100026]   Drosophila melanogaster
FBal0261358 14-3-3epsilon[CPTI100045]   Drosophila melanogaster
FBal0261359 14-3-3epsilon[CPTI100065]   Drosophila melanogaster
FBal0148515 14-3-3epsilon[Scer\UAS.cCa]   Drosophila melanogaster
FBal0263242 14-3-3epsilon[HMS01229]   Drosophila melanogaster

342 Clones

Secondary Identifier DB identifier
AT21339 FBcl0320359
RE11566 FBcl0320360
IP11421 FBcl0320361
EK008008 FBcl0320367
UUGC0005 FBcl0001051
UUGC0192 FBcl0001319
UUGC0467 FBcl0005679
UUGC1122 FBcl0006003
EK068234 FBcl0060680
EK216917 FBcl0060690
EC38570 FBcl0061317
EC38520 FBcl0061329
EC00886 FBcl0061367
EK123334 FBcl0061928
EK175834 FBcl0061934
EK146041 FBcl0061952
EK168414 FBcl0061958
EK144701 FBcl0061964
EK113334 FBcl0061994
EK183908 FBcl0062000
EK043544 FBcl0062004
EK255401 FBcl0062008
EK104128 FBcl0062016
EK278429 FBcl0062020
EK274556 FBcl0062024
EK106201 FBcl0062030
EK041219 FBcl0062036
EK026207 FBcl0062040
EK075857 FBcl0062042
EK288801 FBcl0062048

8 Exons

DB identifier Symbol
FBgn0020238:2 14-3-3epsilon:2
FBgn0020238:3 14-3-3epsilon:3
FBgn0020238:4 14-3-3epsilon:4
FBgn0020238:5 14-3-3epsilon:5
FBgn0020238:1 14-3-3epsilon:1
FBgn0020238:6 14-3-3epsilon:6
FBgn0020238:8 14-3-3epsilon:8
FBgn0020238:7 14-3-3epsilon:7

4 Transcripts

DB identifier Gene
FBtr0083567 14-3-3epsilon
FBtr0083565 14-3-3epsilon
FBtr0083566 14-3-3epsilon
FBtr0083568 14-3-3epsilon

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083565-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083566-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083567-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083568-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083565-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083566-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083567-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083568-3-prime-utr Drosophila melanogaster

Interactions

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Other

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42186 NCBI Entrez Gene identifiers FBgn0020238
67207 BioGRID FBgn0020238

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 15244.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 13501.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 12446.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 17744.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 16322.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 16328.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 12808.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 15067.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 13069.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 13163.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 13834.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 13720.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 14770.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 20335.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 19220.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 16292.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 14630.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 12235.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 15735.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 11420.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 14986.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 9987.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 8354.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 8496.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 7669.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 12197.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 15047.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 15166.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 10629.0
FBgn0020238 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 12133.0

7 Introns

DB identifier
Organism . Name
intron_FBgn0020238:2_FBgn0020238:3 Drosophila melanogaster
intron_FBgn0020238:3_FBgn0020238:4 Drosophila melanogaster
intron_FBgn0020238:4_FBgn0020238:8 Drosophila melanogaster
intron_FBgn0020238:1_FBgn0020238:3 Drosophila melanogaster
intron_FBgn0020238:4_FBgn0020238:6 Drosophila melanogaster
intron_FBgn0020238:4_FBgn0020238:7 Drosophila melanogaster
intron_FBgn0020238:4_FBgn0020238:5 Drosophila melanogaster

25 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage 14-3-3epsilon none 1.137397653   19067489
Lipid storage 14-3-3epsilon none 0.14927069   19067489
ERK signaling 14-3-3epsilon ERK activation reduced strong   17086199
Intracellular Listeria monocytogenes infection 14-3-3epsilon Decreased GFP protein expression moderate   16020693
NFAT signaling 14-3-3epsilon Decreased NFAT translocation 2   16511445
Lipid storage 14-3-3epsilon Smaller sized lipid droplets, more dispersed strong   18408709
Combinatorial effect with methyl methanesulphonate (2) 14-3-3epsilon Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) 14-3-3epsilon none np   20220848
Heat nociception (1) 14-3-3epsilon Developmentally lethal 0   21074052
Heart development and function (1) 14-3-3epsilon none 1   20371351
Notch pathway regulation (4) 14-3-3epsilon none 0   19363474
Notch induced transcription 14-3-3epsilon Downregulation of Notch pathway after Notch stimulation -2.4882 N(delta)ecn Notch stimulation 20959007
Notch induced transcription 14-3-3epsilon none 0.076149 N(delta)ecn Notch stimulation 20959007
Notch induced transcription 14-3-3epsilon none -1.0808 without Notch stimulation 20959007
G2-M DNA damage checkpoint regulation (2) 14-3-3epsilon Increased histone H3 phosphorylation with bleocin 74.89 with bleocin 21205937
G2-M DNA damage checkpoint regulation (2) 14-3-3epsilon Increased histone H3 phosphorylation with doxorubicin 100.24 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) 14-3-3epsilon Increased histone H3 phosphorylation with etoposide 64.42 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) 14-3-3epsilon Increased histone H3 phosphorylation after X-ray exposure 79.23 X-ray exposure 21205937
RTK-Ras-ERK pathway regulation (1) 14-3-3epsilon none -0.13 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) 14-3-3epsilon none -0.96 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) 14-3-3epsilon none 0.33 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) 14-3-3epsilon none -1.05 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation 14-3-3epsilon Upregulation of Hippo pathway -5.72   23263283
Glycosylation regulation (1) 14-3-3epsilon none sp   21203496
Huntingtin (Htt) aggregates formation 14-3-3epsilon Decreased formation of mutant Huntingtin (Httex1-Qn) protein aggregates np   20100940

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