Genomics
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37 Alleles
154 Clones
9 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0010379:3 | Akt1:3 |
| FBgn0010379:1 | Akt1:1 |
| FBgn0010379:4 | Akt1:4 |
| FBgn0010379:5 | Akt1:5 |
| FBgn0010379:6 | Akt1:6 |
| FBgn0010379:7 | Akt1:7 |
| FBgn0010379:8 | Akt1:8 |
| FBgn0010379:9 | Akt1:9 |
| FBgn0010379:2 | Akt1:2 |
4 Transcripts
| DB identifier | Gene |
|---|---|
| FBtr0344470 | Akt1 |
| FBtr0083226 | Akt1 |
| FBtr0083228 | Akt1 |
| FBtr0083227 | Akt1 |
8 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0083226-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0083227-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0083228-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0344470-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0083226-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0083227-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0083228-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0344470-3-prime-utr | Drosophila melanogaster |
Other
94 Pathways
- mTOR signalling,
- Downregulation of ERBB2:ERBB3 signaling,
- AKT phosphorylates targets in the cytosol,
- PI-3K cascade,
- Translocation of GLUT4 to the Plasma Membrane,
- PI3K events in ERBB4 signaling,
- Release of eIF4E,
- eNOS activation and regulation,
- PI3K events in ERBB2 signaling,
- Destabilization of mRNA by KSRP,
- DINR-mediated activation,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- GAB1 signalosome,
- Metabolism of lipids and lipoproteins,
- Signaling by ERBB2,
- B Cell Activation,
- Platelet activation, signaling and aggregation,
- CD28 dependent PI3K/Akt signaling,
- PIP3 activates AKT signaling,
- eNOS activation,
- G-protein beta:gamma signalling,
- Insulin receptor recycling,
- Signaling Pathways,
- AKT phosphorylates targets in the nucleus,
- Metabolism of nitric oxide,
- Signaling by NGF,
- Destabilization of mRNA by Butyrate Response Factor 1 (BRF1),
- Metabolism of RNA,
- Regulation of mRNA Stability by Proteins that Bind AU-rich Elements,
- Fc epsilon receptor (FCERI) signaling,
- Membrane Trafficking,
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation,
- DAP12 signaling,
- IGF1R signaling cascade,
- Regulation of beta-cell development,
- Transcription,
- mTORC1-mediated signalling,
- IRS-mediated signalling,
- Metabolism,
- PI3K/AKT Signaling in Cancer,
- Disease,
- Hemostasis,
- Regulation of Rheb GTPase activity by AMPK,
- PI3K/AKT activation,
- Costimulation by the CD28 family,
- Constitutive PI3K/AKT Signaling in Cancer,
- Role of LAT2/NTAL/LAB on calcium mobilization,
- Signal amplification,
- IRS-related events triggered by IGF1R,
- Innate Immune System,
- PKB-mediated events,
- PI3K Cascade,
- TOR signaling pathway,
- Downstream signal transduction,
- Metabolism of mRNA,
- GPVI-mediated activation cascade,
- Signaling by EGFR,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Insulin receptor signalling cascade,
- Gene Expression,
- Platelet Aggregation (Plug Formation),
- PI Metabolism,
- Synthesis of PIPs at the plasma membrane,
- Downstream signaling of activated FGFR,
- Regulation of AMPK activity via LKB1,
- Signaling by FGFR,
- Insulin receptor mediated signaling,
- Signaling by GPCR,
- mRNA Processing,
- CD28 co-stimulation,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- Inhibition of TSC complex formation by PKB,
- Activation of PKB,
- IRS activation,
- Signaling by ERBB4,
- IRS-related events,
- GPCR downstream signaling,
- Developmental Biology,
- Signaling by EGFR in Cancer,
- CTLA4 inhibitory signaling,
- Adaptive Immune System,
- Insulin signaling pathway,
- Signaling by FGFR in disease,
- AKT-mediated inactivation of FOXO1A,
- Antigen Activates B Cell Receptor Leading to Generation of Second Messengers,
- Signaling by PDGF,
- Signaling by SCF-KIT,
- G beta:gamma signalling through PI3Kgamma,
- DAP12 interactions,
- Immune System,
- Phospholipid metabolism,
- NGF signalling via TRKA from the plasma membrane,
- Regulation of gene expression in beta cells,
- Negative regulation of the PI3K/AKT network
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 41957 | NCBI Entrez Gene identifiers | FBgn0010379 |
| 67008 | BioGRID | FBgn0010379 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
8 Introns
47 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Cell size regulation | Akt1 | none | -0.31 | 19216764 | |
| Lipid storage | Akt1 | none | 0.180274667 | 19067489 | |
| Lipid storage | Akt1 | none | -0.102105052 | 19067489 | |
| ERK signaling | Akt1 | ERK activation increased | strong | 17086199 | |
| Cell morphology | Akt1 | Morphology | np | 14527345 | |
| Cell cycle regulation (1) | Akt1 | none | np | 15616552 | |
| Cell cycle regulation (2) | Akt1 | none | np | 15616552 | |
| Cell size and cell-cycle regulation (1) | Akt1 | Increased G1 DNA content, decreased G2 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Akt1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Akt1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Akt1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Akt1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Akt1 | none | 1.336 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Akt1 | none | 456 | 16496002 | |
| Cell size and cell-cycle regulation (4) | Akt1 | none | below threshold | 16496002 | |
| P. aeruginosa infection | Akt1 | P. aeruginosa invasion decreased | np | 18369477 | |
| DFoxO signaling | Akt1 | Decreased dFoxO reporter activity | 0.08 | 18815370 | |
| Combinatorial effect with methyl methanesulphonate (2) | Akt1 | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | Akt1 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | Akt1 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | Akt1 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | Akt1 | Clumpy Z-line (irregular aggregates) | np | 20220848 | |
| Heat nociception (1) | Akt1 | Developmentally lethal | 0 | 21074052 | |
| Heart development and function (1) | Akt1 | Adult lethal | 0.6 | 20371351 | |
| Heart development and function (2) | Akt1 | none | 2.91 | 20371351 | |
| Serratia marcescens infection (1) | Akt1 | Decreased viability after Serratia marcescens infection | -3.30985915492957 | 19520911 | |
| Serratia marcescens infection (2) | Akt1 | none | sp | 19520911 | |
| Serratia marcescens infection (4) | Akt1 | none | sp | 19520911 | |
| Notch pathway regulation (4) | Akt1 | Completely lethal (pupal) | sp | 19363474 | |
| Akt-TOR pathway negative feedback regulation | Akt1 | Decreased dAkt phosphorylation after insulin stimulation | -9.8 | 10 min insulin stimulation | 20585550 |
