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Gene : htl D. melanogaster

DB identifier  ? FBgn0010389 Secondary Identifier  ? CG7223
Name  ? heartless Source  FlyBase
  • synonyms:
  • DPR3,
  • CT39172,
  • FGF receptor,
  • FGFR2,
  • FGFR,
  • Tk1,
  • FR1,
  • FBan0007223,
  • j372,
  • Fibroblast growth factor receptor,
  • Heartless,
  • Fibroblast growth factor receptor 1,
  • DFR-1,
  • FGF-R2,
  • HD-38,
  • FBgn0022791,
  • DFGF-R1,
  • FBgn0010389,
  • i150,
  • Htl,
  • FBgn0004599,
  • DmHD-38,
  • DFGF-R2,
  • DFR1,
  • CT22273,
  • i79,
  • CG7223,
  • i100,
  • DFR1/DFGF-R2,
  • DTRK(FR1),
  • Dtk1,
  • HTL/FGFR1,
  • EMS2

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40 Alleles

DB identifier Symbol Allele Class Organism
FBal0210969 htl[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0179438 htl[d11749]   Drosophila melanogaster
FBal0179439 htl[d07559]   Drosophila melanogaster
FBal0179437 htl[f03388]   Drosophila melanogaster
FBal0241097 htl[dsRNA.Scer\UAS.cFa]   Drosophila melanogaster
FBal0212509 htl[MB01532]   Drosophila melanogaster
FBal0159151 htl[d07110]   Drosophila melanogaster
FBal0057259 htl[P16]   Drosophila melanogaster
FBal0130207 htl[BG01331]   Drosophila melanogaster
FBal0061362 htl[S1-28]   Drosophila melanogaster
FBal0057262 htl[AD332]   Drosophila melanogaster
FBal0061363 htl[E12]   Drosophila melanogaster
FBal0057267 htl[Delta30]   Drosophila melanogaster
FBal0057263 htl[AD326]   Drosophila melanogaster
FBal0155193 htl[dsRNA.cKa]   Drosophila melanogaster
FBal0057258 htl[YY262] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0057264 htl[AB42] amorphic allele - genetic evidence, loss of function allele Drosophila melanogaster
FBal0150432 htl[EMS2]   Drosophila melanogaster
FBal0061364 htl[80]   Drosophila melanogaster
FBal0057257 htl[ZZ81]   Drosophila melanogaster
FBal0057265 htl[AB111]   Drosophila melanogaster
FBal0061366 htl[108]   Drosophila melanogaster
FBal0057260 htl[LH14]   Drosophila melanogaster
FBal0150431 htl[J372]   Drosophila melanogaster
FBal0155192 htl[dsRNA.si.cKa]   Drosophila melanogaster
FBal0086540 htl[unspecified]   Drosophila melanogaster
FBal0061365 htl[117]   Drosophila melanogaster
FBal0057266 htl[Delta51]   Drosophila melanogaster
FBal0090413 htl[DN.Scer\UAS.cMb]   Drosophila melanogaster
FBal0057261 htl[DN.Scer\UAS]   Drosophila melanogaster

37 Clones

Secondary Identifier DB identifier
DPiM_LD32130 FBcl0741206
CK00175 FBcl0058981
CK00010 FBcl0058983
EK181405 FBcl0062720
EK022861 FBcl0062780
EK114327 FBcl0062794
EK260309 FBcl0062800
EK268759 FBcl0062808
LD32130 FBcl0170992
LP11588 FBcl0185552
RE20675 FBcl0215253
RE26668 FBcl0215503
RE36917 FBcl0215504
RE19829 FBcl0215531
RH13594 FBcl0257192
RH03589 FBcl0257245
RH46663 FBcl0257274
RH55295 FBcl0257278
RH03982 FBcl0257306
RH64250 FBcl0257309
EC055440 FBcl0299974
EK098613 FBcl0320339
CK01.25D.H2 FBcl0462577
CK01.127D.E7 FBcl0462580
CK01.23B.G4 FBcl0462502
CK01.23B.F11 FBcl0462548
RP003428954 FBcl0545821
RP003082853 FBcl0545822
RP003195910 FBcl0545823
RP003433629 FBcl0545824

4 Exons

DB identifier Symbol
FBgn0010389:4 htl:4
FBgn0010389:1 htl:1
FBgn0010389:2 htl:2
FBgn0010389:3 htl:3

3 Transcripts

DB identifier Gene
FBtr0083548 htl
FBtr0083550 htl
FBtr0083549 htl

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083548-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083549-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083550-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083548-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083549-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083550-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42160 NCBI Entrez Gene identifiers FBgn0010389
67184 BioGRID FBgn0010389

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from UniProt  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1131.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1089.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 277.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 112.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 460.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 142.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 16.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 80.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 74.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 35.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 69.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 668.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 808.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 203.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1796.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 66.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 257.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 151.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 198.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1700.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 732.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 3254.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 31.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 76.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 132.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 45.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 373.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 583.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 327.0
FBgn0010389 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 326.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0010389:4_FBgn0010389:1 Drosophila melanogaster
intron_FBgn0010389:2_FBgn0010389:1 Drosophila melanogaster
intron_FBgn0010389:3_FBgn0010389:1 Drosophila melanogaster

37 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage htl none -0.382080578   19067489
Lipid storage htl none 0.627042869   19067489
Cell cycle regulation (1) htl Increased cytokinetic index sp   15616552
Cell cycle regulation (2) htl none np   15616552
Cell size and cell-cycle regulation (1) htl Increased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) htl none sp   16496002
Cell size and cell-cycle regulation (1) htl none sp   16496002
Heart development and function htl Cardiac precursors specification defects np   14684833
Muscle morphogenesis and function (1) htl Lethal np   20220848
Muscle morphogenesis and function (1) htl Lethal np   20220848
Muscle morphogenesis and function (1) htl Lethal np   20220848
Muscle morphogenesis and function (1) htl Lethal np   20220848
Muscle morphogenesis and function (3) htl Split myofibril, spotty (discontinuous) Z-line np   20220848
Heat nociception (1) htl Increased noxious heat avoidance 2.67   21074052
Heat nociception (1) htl none -0.23   21074052
Heat nociception (1) htl none -0.62   21074052
Heart development and function (1) htl none 1   20371351
Heart development and function (1) htl none 1   20371351
Heart development and function (2) htl none 2.81   20371351
Serratia marcescens infection (1) htl none -1.05454545454545   19520911
Serratia marcescens infection (1) htl Decreased viability after Serratia marcescens infection -2.6701030927835   19520911
Serratia marcescens infection (2) htl Decreased viability after Serratia marcescens infection sp   19520911
Serratia marcescens infection (4) htl Decreased viability after Serratia marcescens infection sp   19520911
Serratia marcescens infection (5) htl Viable np   19520911
Notch pathway regulation (4) htl Bristle morphology defects 9   19363474
Notch pathway regulation (4) htl none 0   19363474
Notch pathway regulation (4) htl Planar polarity defects 3   19363474
Notch pathway regulation (4) htl none 0   19363474
Adiposity regulation (1) htl none 0.338   20074523
Actin organization and cell morphology (1) htl none np   19265526

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