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Gene : Taf1 D. melanogaster

DB identifier  ? FBgn0010355 Secondary Identifier  ? CG17603
Name  ? TBP-associated factor 1 Source  FlyBase
  • synonyms:
  • FBgn0010420,
  • unnamed,
  • EfW1,
  • dTAF[[II]]250,
  • Suppressor of Ras85D 3-5,
  • TAF[[II]]250,
  • TAF250,
  • TAF250/230,
  • p230,
  • FBgn0016735,
  • TFIID TAF250,
  • TAFII250,
  • TBP-associated factor 250,
  • l(3)84Ab,
  • FBgn0010355,
  • FBgn0004775,
  • TFIID 230 kda subunit,
  • TAF[II]250,
  • TAF1,
  • BG:DS00004.13,
  • TAF[[II]]230,
  • TAF[[II]],
  • CG17603,
  • cel,
  • dTAFII250,
  • TFIID,
  • TBP-associated factor 250kD,
  • d230,
  • dTAF[[II]]230,
  • cell,
  • TAF200,
  • TBP-associated factor,
  • dTAF230,
  • FBan0017603,
  • dmTAF[[II]]230,
  • TATA-associated factor 250,
  • dmTAF1,
  • Taf1p,
  • TAF230,
  • dTAF250,
  • TAFII-250,
  • cell lethal,
  • TAF,
  • TAF[[II]]250/230,
  • SR3-5

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31 Alleles

DB identifier Symbol Allele Class Organism
FBal0181312 Taf1[e02697]   Drosophila melanogaster
FBal0104706 Taf1[EP421]   Drosophila melanogaster
FBal0058159 Taf1[Act5C.PF]   Drosophila melanogaster
FBal0104707 Taf1[EP421-EX1]   Drosophila melanogaster
FBal0001581 Taf1[4]   Drosophila melanogaster
FBal0001590 Taf1[13]   Drosophila melanogaster
FBal0034341 Taf1[R14]   Drosophila melanogaster
FBal0048987 Taf1[XS-2232]   Drosophila melanogaster
FBal0001584 Taf1[7]   Drosophila melanogaster
FBal0095610 Taf1[S-625]   Drosophila melanogaster
FBal0001583 Taf1[6]   Drosophila melanogaster
FBal0001588 Taf1[11]   Drosophila melanogaster
FBal0001579 Taf1[2]   Drosophila melanogaster
FBal0001587 Taf1[10]   Drosophila melanogaster
FBal0001589 Taf1[12]   Drosophila melanogaster
FBal0001592 Taf1[15]   Drosophila melanogaster
FBal0001580 Taf1[3]   Drosophila melanogaster
FBal0001591 Taf1[14]   Drosophila melanogaster
FBal0001582 Taf1[5]   Drosophila melanogaster
FBal0048986 Taf1[S-136]   Drosophila melanogaster
FBal0001586 Taf1[9]   Drosophila melanogaster
FBal0001585 Taf1[8]   Drosophila melanogaster
FBal0001578 Taf1[1]   Drosophila melanogaster
FBal0262690 Taf1[GL00219]   Drosophila melanogaster
FBal0193984 Taf1[CTK]   Drosophila melanogaster
FBal0193985 Taf1[dsRNA.cMa]   Drosophila melanogaster
FBal0194222 Taf1[dsRNA.cWa]   Drosophila melanogaster
FBal0208705 Taf1[GD4594]   Drosophila melanogaster
FBal0248177 Taf1[HMS00416]   Drosophila melanogaster
FBal0230735 Taf1[KK100418]   Drosophila melanogaster

83 Clones

Secondary Identifier DB identifier
EK016001 FBcl0024128
EK049501 FBcl0024142
EK237405 FBcl0024154
EK227842 FBcl0024170
EK165828 FBcl0024184
EK173460 FBcl0024198
EK189318 FBcl0024404
EK252950 FBcl0025066
EK235252 FBcl0025084
EK263225 FBcl0025120
EK140462 FBcl0025138
EK020915 FBcl0025210
EK124723 FBcl0025228
EK202158 FBcl0025312
CK01486 FBcl0059011
EC33660 FBcl0061797
EC19960 FBcl0061811
EP16535 FBcl0074913
EP17928 FBcl0074969
GH17990 FBcl0127205
GM01075 FBcl0137941
GM03821 FBcl0137943
LD06414 FBcl0159668
LD05618 FBcl0159670
LD11315 FBcl0159694
LD13531 FBcl0159711
LD02516 FBcl0159783
LD33825 FBcl0174658
LD28190 FBcl0174665
LD42311 FBcl0174676

17 Exons

DB identifier Symbol
FBgn0010355:1 Taf1:1
FBgn0010355:2 Taf1:2
FBgn0010355:4 Taf1:4
FBgn0010355:5 Taf1:5
FBgn0010355:6 Taf1:6
FBgn0010355:7 Taf1:7
FBgn0010355:8 Taf1:8
FBgn0010355:9 Taf1:9
FBgn0010355:10 Taf1:10
FBgn0010355:11 Taf1:11
FBgn0010355:12 Taf1:12
FBgn0010355:13 Taf1:13
FBgn0010355:15 Taf1:15
FBgn0010355:17 Taf1:17
FBgn0010355:14 Taf1:14
FBgn0010355:16 Taf1:16
FBgn0010355:3 Taf1:3

5 Transcripts

DB identifier Gene
FBtr0081685 Taf1
FBtr0081686 Taf1
FBtr0301622 Taf1
FBtr0081684 Taf1
FBtr0304903 Taf1

10 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081684-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0081685-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0081686-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0301622-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0304903-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081684-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081685-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081686-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0301622-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0304903-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40813 NCBI Entrez Gene identifiers FBgn0010355
66011 BioGRID FBgn0010355

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1394.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1211.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1244.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1267.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1859.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 393.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1039.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1140.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 856.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 986.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1015.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 684.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 918.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1212.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 886.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 677.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1088.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 879.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 764.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 939.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1113.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1189.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 934.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 865.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 710.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2238.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2045.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1526.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 994.0
FBgn0010355 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1177.0

19 Introns

DB identifier
Organism . Name
intron_FBgn0010355:1_FBgn0010355:2 Drosophila melanogaster
intron_FBgn0010355:2_FBgn0010355:4 Drosophila melanogaster
intron_FBgn0010355:4_FBgn0010355:5 Drosophila melanogaster
intron_FBgn0010355:5_FBgn0010355:6 Drosophila melanogaster
intron_FBgn0010355:6_FBgn0010355:7 Drosophila melanogaster
intron_FBgn0010355:7_FBgn0010355:8 Drosophila melanogaster
intron_FBgn0010355:8_FBgn0010355:9 Drosophila melanogaster
intron_FBgn0010355:9_FBgn0010355:10 Drosophila melanogaster
intron_FBgn0010355:10_FBgn0010355:11 Drosophila melanogaster
intron_FBgn0010355:11_FBgn0010355:12 Drosophila melanogaster
intron_FBgn0010355:12_FBgn0010355:13 Drosophila melanogaster
intron_FBgn0010355:13_FBgn0010355:14 Drosophila melanogaster
intron_FBgn0010355:14_FBgn0010355:15 Drosophila melanogaster
intron_FBgn0010355:15_FBgn0010355:16 Drosophila melanogaster
intron_FBgn0010355:16_FBgn0010355:17 Drosophila melanogaster
intron_FBgn0010355:15_FBgn0010355:17 Drosophila melanogaster
intron_FBgn0010355:13_FBgn0010355:15 Drosophila melanogaster
intron_FBgn0010355:2_FBgn0010355:3 Drosophila melanogaster
intron_FBgn0010355:3_FBgn0010355:5 Drosophila melanogaster

24 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Taf1 Decreased lipid droplet area -1.883472467   19067489
Lipid storage Taf1 Decreased lipid droplet area -2.231796668   19067489
ERK signaling Taf1 ERK activation increased weak   17086199
Cell cycle regulation (1) Taf1 Increased S DNA content, increased G2/M DNA content, decreased mitotic index, all mitotic defects sp   15616552
Cell cycle regulation (2) Taf1 Increased S DNA content or increased number of aneuploid cells, increased G2 DNA content np   15616552
Wnt signaling Taf1 Increased Wnt reporter activity 7.7   15817814
Constitutive protein secretion and Golgi organization (1) Taf1 Decreased horseradish peroxidase protein expression sp   16452979
Dendrite pattern formation Taf1 none np   16547170
Combinatorial effect with methyl methanesulphonate (2) Taf1 none sp   19543366
Muscle morphogenesis and function (1) Taf1 Lethal np   20220848
Regulated secretory pathway biogenesis (1) Taf1 none 6.5   21149569
Heart development and function (1) Taf1 none 1   20371351
Notch pathway regulation (4) Taf1 Notum malformation death 10   19363474
PGN-induced dJNK phosphorylation Taf1 Increased P-JNK protein expression with PGN 5.08 15 min PGN induction 19893628
Self-renewal and differentiation in neural stem cells Taf1 GFP aggregates number, GFP aggregates size, neuroblast cell shape, ganglion mother cell shorter lineages, ganglion mother cell shape, neuroblast underproliferation, lethal sp   21549331
Vaccinia virus infection Taf1 none sp   20585561
Secretory pathway regulation Taf1 Decreased BiP signal peptide and firefly luciferase fusion protein expression < -2   19942856
RTK-Ras-ERK pathway regulation (1) Taf1 none -1.45 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Taf1 none -0.51 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Taf1 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.13 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Taf1 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.76 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Taf1 none -1.2   23263283
Srp/Lz-induced transcriptional activation Taf1 Decreased Srp/Lz-induced transcription -5.77   20368357
Glycosylation regulation (1) Taf1 none sp   21203496

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