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Gene : E2f D. melanogaster

DB identifier  ? FBgn0011766 Secondary Identifier  ? CG6376
Name  ? E2F transcription factor Source  FlyBase
  • synonyms:
  • DRTF1/E2F,
  • E2-promoter binding factor,
  • dE2F,
  • FBgn0011520,
  • E(var)93E,
  • def21,
  • CG6376,
  • E2F-1,
  • E2F1,
  • FBan0006376,
  • FBgn0013944,
  • FBgn0011343,
  • Evar(3)164,
  • dE2F1,
  • E(var)3-93E,
  • FBgn0016652,
  • l(3)07172,
  • E(var)3-95E,
  • l(3)j3C2,
  • FBgn0011767,
  • drosE2F1,
  • FBgn0010918,
  • E(Sev-CycE)3A,
  • FBgn0011766,
  • l(3)rM729,
  • Dp,
  • DmE2F-1,
  • E2F,
  • FBgn0011351,
  • l(3)j3B1

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96 Alleles

DB identifier Symbol Allele Class Organism
FBal0282613 E2f[dsRNA.Scer\UAS.cJa]   Drosophila melanogaster
FBal0247709 E2f[MI00618]   Drosophila melanogaster
FBal0248936 E2f[Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0248937 E2f[PIP-3A.Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0248938 E2f[PIP-7A.Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0248939 E2f[PIP-7del.Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0282985 E2f[MI07609]   Drosophila melanogaster
FBal0264087 E2f[MI03553]   Drosophila melanogaster
FBal0268280 E2f[mir-11-KO.w+]   Drosophila melanogaster
FBal0268281 E2f[mir-11-R.w-]   Drosophila melanogaster
FBal0183916 E2f[DG02609]   Drosophila melanogaster
FBal0183914 E2f[LA00365]   Drosophila melanogaster
FBal0183915 E2f[EY16535]   Drosophila melanogaster
FBal0264144 E2f[Delta1]   Drosophila melanogaster
FBal0183907 E2f[d06292]   Drosophila melanogaster
FBal0183908 E2f[d05852]   Drosophila melanogaster
FBal0183911 E2f[d02760]   Drosophila melanogaster
FBal0183902 E2f[f06935]   Drosophila melanogaster
FBal0245931 E2f[JF01741]   Drosophila melanogaster
FBal0160588 E2f[EY14408]   Drosophila melanogaster
FBal0183909 E2f[d03985]   Drosophila melanogaster
FBal0183910 E2f[d02846]   Drosophila melanogaster
FBal0183912 E2f[d01508]   Drosophila melanogaster
FBal0183903 E2f[f05965]   Drosophila melanogaster
FBal0183904 E2f[f05222]   Drosophila melanogaster
FBal0183905 E2f[f01988]   Drosophila melanogaster
FBal0183906 E2f[f01550]   Drosophila melanogaster
FBal0183913 E2f[c06065]   Drosophila melanogaster
FBal0160590 E2f[EY05005]   Drosophila melanogaster
FBal0160589 E2f[EY08459]   Drosophila melanogaster

118 Clones

Secondary Identifier DB identifier
UUGC1042 FBcl0005591
AT04650 FBcl0023769
AT11090 FBcl0023771
CK00303 FBcl0060141
EK098141 FBcl0072854
EK268914 FBcl0072912
EK208524 FBcl0072916
EK184031 FBcl0072926
EK104414 FBcl0072936
EK196863 FBcl0072946
EK226045 FBcl0072950
EK162001 FBcl0072964
EK142931 FBcl0072968
EK158660 FBcl0072974
EK307701 FBcl0072982
EK030009 FBcl0072986
EK183925 FBcl0072992
EK148644 FBcl0072998
EK195755 FBcl0073002
EK162210 FBcl0073006
EK148436 FBcl0073016
EK173009 FBcl0073028
EK294205 FBcl0073034
EK206926 FBcl0073038
EK307745 FBcl0073048
EK067010 FBcl0073058
EK223111 FBcl0073250
EK067940 FBcl0073258
EK099038 FBcl0073344
EK276842 FBcl0073518

13 Exons

DB identifier Symbol
FBgn0011766:13 E2f:13
FBgn0011766:12 E2f:12
FBgn0011766:9 E2f:9
FBgn0011766:7 E2f:7
FBgn0011766:6 E2f:6
FBgn0011766:4 E2f:4
FBgn0011766:3 E2f:3
FBgn0011766:2 E2f:2
FBgn0011766:11 E2f:11
FBgn0011766:8 E2f:8
FBgn0011766:1 E2f:1
FBgn0011766:10 E2f:10
FBgn0011766:5 E2f:5

4 Transcripts

DB identifier Gene
FBtr0084117 E2f
FBtr0084119 E2f
FBtr0084118 E2f
FBtr0334678 E2f

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0084117-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0084118-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0084119-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334678-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084117-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084118-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084119-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334678-3-prime-utr Drosophila melanogaster

Interactions

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Other

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42550 NCBI Entrez Gene identifiers FBgn0011766
67516 BioGRID FBgn0011766

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2662.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2400.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1087.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2658.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2156.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2778.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 3138.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2256.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2439.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2066.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 3693.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1770.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 3941.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1334.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2670.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2113.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2831.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2200.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2363.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2191.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 4327.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 3245.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2181.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2252.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2674.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4658.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2579.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 3596.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2828.0
FBgn0011766 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2644.0

13 Introns

DB identifier
Organism . Name
intron_FBgn0011766:10_FBgn0011766:8 Drosophila melanogaster
intron_FBgn0011766:8_FBgn0011766:6 Drosophila melanogaster
intron_FBgn0011766:6_FBgn0011766:5 Drosophila melanogaster
intron_FBgn0011766:5_FBgn0011766:4 Drosophila melanogaster
intron_FBgn0011766:4_FBgn0011766:3 Drosophila melanogaster
intron_FBgn0011766:3_FBgn0011766:1 Drosophila melanogaster
intron_FBgn0011766:13_FBgn0011766:12 Drosophila melanogaster
intron_FBgn0011766:12_FBgn0011766:9 Drosophila melanogaster
intron_FBgn0011766:9_FBgn0011766:7 Drosophila melanogaster
intron_FBgn0011766:7_FBgn0011766:6 Drosophila melanogaster
intron_FBgn0011766:6_FBgn0011766:4 Drosophila melanogaster
intron_FBgn0011766:3_FBgn0011766:2 Drosophila melanogaster
intron_FBgn0011766:11_FBgn0011766:8 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage E2f none 1.707395202   19067489
Lipid storage E2f none 0.61371399   19067489
ERK signaling E2f ERK activation reduced strong   17086199
Cytokinesis regulation E2f Binucleate cells with decreased viability weak   15547975
Intracellular Listeria monocytogenes infection E2f Increased GFP protein expression weak   16020693
Innate immunity E2f Increased IMD reporter activity np   16163390
Constitutive protein secretion and Golgi organization (1) E2f Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) E2f Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size, increased G2 cell size sp   16496002
Cell size and cell-cycle regulation (1) E2f none sp   16496002
Cell size and cell-cycle regulation (1) E2f Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size, increased G2 cell size sp   16496002
Cell size and cell-cycle regulation (1) E2f none sp   16496002
Cell size and cell-cycle regulation (2) E2f none 1.144   16496002
Cell size and cell-cycle regulation (2) E2f none 1.275   16496002
Cell size and cell-cycle regulation (3) E2f none 424   16496002
Cell size and cell-cycle regulation (3) E2f none 426   16496002
Heart development and function E2f Posterior portion assembly defects np   14684833
Dendrite pattern formation E2f Increased arborization np   16547170
Mutant human huntingtin aggregation E2f Increased mutant human huntingtin aggregation 1.5 - 2   19789644
Muscle morphogenesis and function (1) E2f none np   20220848
Muscle morphogenesis and function (1) E2f none np   20220848
Heat nociception (1) E2f none -1.17   21074052
Heat nociception (1) E2f none -1.17   21074052
Heart development and function (1) E2f none 1   20371351
Serratia marcescens infection (1) E2f none 0.905882352941176   19520911
Notch pathway regulation (4) E2f Bristle morphology defects, notum malformation migration, notum malformation death sp   19363474
Notch pathway regulation (4) E2f Bristle morphology defects, notum malformation migration sp   19363474
Adiposity regulation (1) E2f none 0.016   20074523
RTK-Ras-ERK pathway regulation (1) E2f Decreased ERK phosphorylation after EGF stimulation -2.58 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) E2f Decreased ERK phosphorylation after EGF stimulation -2.67 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) E2f Increased ERK phosphorylation after sSpitz and EGF stimulation 10.06 10 minutes sSpitz stimulation 22028469

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