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Gene : RnrS D. melanogaster

DB identifier  ? FBgn0011704 Secondary Identifier  ? CG8975
Name  ? Ribonucleoside diphosphate reductase small subunit Source  FlyBase
  • synonyms:
  • CG8975,
  • DmRNR2,
  • FBgn0062214,
  • FBgn0011704,
  • Ribonucleotide reductase small subunit,
  • dRNR2,
  • FBan0008975,
  • anon-WO0118547.148,
  • ribonucleoside-diphosphate reductase small subunit,
  • RNR2,
  • RNrS,
  • Ribonucleotide reductase

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7 Alleles

DB identifier Symbol Allele Class Organism
FBal0220900 RnrS[G6051]   Drosophila melanogaster
FBal0257335 RnrS[HMS00651]   Drosophila melanogaster
FBal0181850 RnrS[f02017]   Drosophila melanogaster
FBal0181851 RnrS[c01630]   Drosophila melanogaster
FBal0287497 RnrS[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0208313 RnrS[GD1944]   Drosophila melanogaster
FBal0276234 RnrS[NIG.8975R]   Drosophila melanogaster

112 Clones

Secondary Identifier DB identifier
EC03145 FBcl0067457
EC02945 FBcl0067459
EC35113 FBcl0067461
EK114029 FBcl0089834
EK050760 FBcl0090342
EK249543 FBcl0090602
EK240930 FBcl0090740
EK295345 FBcl0090798
EK279244 FBcl0090828
EK302046 FBcl0091454
GM10962 FBcl0141660
LD03958 FBcl0162102
LD41588 FBcl0177693
LD32770 FBcl0177696
RE37776 FBcl0235464
RE17161 FBcl0235480
RE60151 FBcl0235487
RE43834 FBcl0235490
RE35008 FBcl0235504
RE45947 FBcl0235505
RE36560 FBcl0235508
RE25564 FBcl0235513
RE62771 FBcl0235516
RE32280 FBcl0235517
RE48623 FBcl0235518
RE51423 FBcl0235520
RE40653 FBcl0235523
RE63674 FBcl0235525
RE47258 FBcl0235527
RE20781 FBcl0235640

3 Exons

DB identifier Symbol
FBgn0011704:3 RnrS:3
FBgn0011704:2 RnrS:2
FBgn0011704:1 RnrS:1

1 Transcripts

DB identifier Gene
FBtr0088046 RnrS

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0088046-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088046-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
36280 NCBI Entrez Gene identifiers FBgn0011704
62064 BioGRID FBgn0011704

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2258.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 3180.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1163.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1949.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2517.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 4162.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2074.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2297.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1718.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1550.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1510.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1223.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1835.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1130.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1782.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 870.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1239.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2049.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1667.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1467.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2193.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2470.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1207.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1575.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1829.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 6490.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2427.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 4816.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2830.0
FBgn0011704 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1804.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0011704:3_FBgn0011704:2 Drosophila melanogaster
intron_FBgn0011704:2_FBgn0011704:1 Drosophila melanogaster

27 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage RnrS none 7.558425697   19067489
Lipid storage RnrS none -1.255344303   19067489
ERK signaling RnrS ERK activation reduced weak   17086199
Cytokinesis regulation RnrS Binucleate cells with decreased viability weak   15547975
Intracellular Listeria monocytogenes infection RnrS Increased GFP protein expression moderate   16020693
Constitutive protein secretion and Golgi organization (1) RnrS Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) RnrS none sp   16496002
Lipid storage RnrS Fewer lipid droplets strong   18408709
Combinatorial effect with methyl methanesulphonate (2) RnrS Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) RnrS Lethal np   20220848
Muscle morphogenesis and function (3) RnrS none np   20220848
Heat nociception (1) RnrS none -0.06   21074052
Heart development and function (1) RnrS none 1   20371351
Serratia marcescens infection (1) RnrS none -0.492063492063492   19520911
Notch pathway regulation (4) RnrS Loss of bristles, notum malformation death sp   19363474
Notch induced transcription RnrS none 2.3185 without Notch stimulation 20959007
Notch induced transcription RnrS none 0.45921 N(delta)ecn Notch stimulation 20959007
Notch induced transcription RnrS Downregulation of Notch pathway after Notch stimulation -2.5675 N(delta)ecn Notch stimulation 20959007
Self-renewal and differentiation in neural stem cells RnrS GFP aggregates number, GFP aggregates size, neuroblast larger cell size, neuroblast less large cells, neuroblast cell shape, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with larger neuroblast cell size, neuroblast underprolifer sp   21549331
Adiposity regulation (1) RnrS none -0.265   20074523
RTK-Ras-ERK pathway regulation (1) RnrS Decreased ERK phosphorylation after EGF stimulation -2.86 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) RnrS none -0.59 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) RnrS Increased ERK phosphorylation after sSpitz and EGF stimulation 2.54 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) RnrS Increased ERK phosphorylation after sSpitz and EGF stimulation 2.99 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation RnrS none -1.85   23263283
Srp/Lz-induced transcriptional activation RnrS Decreased Srp/Lz-induced transcription -5.46   20368357
Glycosylation regulation (1) RnrS none sp   21203496

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