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Protein : FBpp0099494 D. melanogaster

Primary Accession  ? O96553 Organism . Name  Drosophila melanogaster
MD5 Checksum  c3fcea56d9dd34c876b401ec9b2a6f0f UniProt Accession  O96553
UniProt Name  C1TC_DROME GenBank Identifier  AAX52944
Is UniProt Canonical  true Is Fragment  false
Length  968 Molecular Weight  103504
Name  C-1-tetrahydrofolate synthase, cytoplasmic Secondary Identifier  FBpp0099494

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1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0020385 CG4067 pug pugilist FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

5 Cross References

Source . Name

Subject . Primary Identifier
NP_477254.1 RefSeq FBpp0099494
Dm.14326 UniGene FBpp0099494
NP_731490.1 RefSeq FBpp0099494
NP_001014614.1 RefSeq FBpp0099494
NP_731489.2 RefSeq FBpp0099494

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

3 Ec Numbers

Identifier Description  

2 Locations

Located On . Primary Identifier
Start End Strand
3R 6522454 6528867 1
3R 6522454 6528867 1

23 Pathways

Identifier Name
112201 Metabolism
93230 Metabolism of folate and pterines
96904 Metabolism of vitamins and cofactors
99870 Metabolism of water-soluble vitamins and cofactors
172141 Defective HLCS causes multiple carboxylase deficiency
170704 Defective BTD causes biotidinase deficiency
170877 Defective MMAA causes methylmalonic aciduria type cblA
171816 Defective MUT causes methylmalonic aciduria mut type
170863 Defective CD320 causes methylmalonic aciduria
170480 Defects in biotin (Btn) metabolism
170427 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
170479 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
170421 Defective MMAB causes methylmalonic aciduria type cblB
172030 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
172052 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
172351 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
171186 Defective GIF causes intrinsic factor deficiency
172253 Defective CUBN causes hereditary megaloblastic anemia 1
172121 Defective TCN2 causes hereditary megaloblastic anemia
172488 Defects in cobalamin (B12) metabolism
172146 Defective AMN causes hereditary megaloblastic anemia 1
170642 Defects in vitamin and cofactor metabolism
118381 Disease

8 Protein Domains

DB identifier Name Short Name Type
IPR027417 P-loop containing nucleoside triphosphate hydrolase P-loop_NTPase Domain
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase THF_DH/CycHdrlase Family
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DH/CycHdrlase_cat_dom Domain
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site THF_DH/CycHdrlase_CS Conserved_site
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DH/CycHdrlase_NAD-bd_dom Domain
IPR000559 Formate-tetrahydrofolate ligase, FTHFS Formate_THF_ligase Family
IPR020628 Formate-tetrahydrofolate ligase, FTHFS, conserved site Formate_THF_ligase_CS Conserved_site

2 Transcripts

DB identifier Gene
FBtr0082264 pug
FBtr0100144 pug