Genomics
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22 Alleles
318 Clones
6 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0034258:2 | eIF3-S8:2 |
| FBgn0034258:3 | eIF3-S8:3 |
| FBgn0034258:5 | eIF3-S8:5 |
| FBgn0034258:1 | eIF3-S8:1 |
| FBgn0034258:4 | eIF3-S8:4 |
| FBgn0034258:6 | eIF3-S8:6 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0086836-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0340269-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0086836-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0340269-3-prime-utr | Drosophila melanogaster |
Other
43 Pathways
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Pre-transcription Events,
- Transport of Mature Transcript to Cytoplasm,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- RNA Polymerase II Transcription Elongation,
- Post-Elongation Processing of the Transcript,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Cap-dependent Translation Initiation,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Translation initiation complex formation,
- mRNA Processing,
- Cleavage of Growing Transcript in the Termination Region,
- Processing of Capped Intronless Pre-mRNA,
- Recycling of eIF2:GDP,
- Ribosomal scanning and start codon recognition,
- Formation of RNA Pol II elongation complex,
- RNA Polymerase II Transcription Initiation,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Transport of the SLBP Dependant Mature mRNA,
- Eukaryotic Translation Initiation,
- Processing of Intronless Pre-mRNAs,
- Elongation arrest and recovery,
- RNA Polymerase II Transcription Termination,
- Formation of the ternary complex, and subsequently, the 43S complex,
- Transcription,
- Formation of a pool of free 40S subunits,
- Formation of the Early Elongation Complex,
- Transport of the SLBP independent Mature mRNA,
- Translation,
- Post-Elongation Processing of Intronless pre-mRNA,
- mRNA Capping,
- RNA Pol II CTD phosphorylation and interaction with CE,
- RNA Polymerase II Promoter Escape,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- RNA Polymerase II Transcription,
- Gene Expression,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Metabolism of proteins,
- Processing of Capped Intron-Containing Pre-mRNA,
- SLBP independent Processing of Histone Pre-mRNAs
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 37005 | NCBI Entrez Gene identifiers | FBgn0034258 |
| 62691 | BioGRID | FBgn0034258 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
5 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF3-S8 | Increased lipid droplet area | 3.0394555 | 19067489 | |
| Lipid storage | eIF3-S8 | Increased lipid droplet area | 3.428291729 | 19067489 | |
| Cytokinesis regulation | eIF3-S8 | Binucleate cells | weak | 15547975 | |
| Constitutive protein secretion and Golgi organization (1) | eIF3-S8 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | eIF3-S8 | none | sp | 16496002 | |
| Influenza replication | eIF3-S8 | Decreased Influenza replication | -1.61/-3.21 | 18615016 | |
| Mitochondrial biogenesis and function | eIF3-S8 | Increased mitochondrial citrate synthase activity, decreased viability | 1.281 | 18042644 | |
| Lipid storage | eIF3-S8 | Normal/larger sized lipid droplets, highly condensed | strong | 18408709 | |
| Muscle morphogenesis and function (1) | eIF3-S8 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF3-S8 | Split myofibril, fading Z-line | np | 20220848 | |
| Heat nociception (1) | eIF3-S8 | Developmentally lethal | -1.17 | 21074052 | |
| Heat nociception (1) | eIF3-S8 | none | 0.69 | 21074052 | |
| Heart development and function (1) | eIF3-S8 | Larval lethal | 0.25 | 20371351 | |
| Serratia marcescens infection (1) | eIF3-S8 | none | -1.44680851063829 | 19520911 | |
| Serratia marcescens infection (1) | eIF3-S8 | none | 0.238095238095238 | 19520911 | |
| Notch pathway regulation (4) | eIF3-S8 | Completely lethal (before pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | eIF3-S8 | Completely lethal (before pupal) | sp | 19363474 | |
| Notch pathway regulation (1) | eIF3-S8 | Upregulation of Notch pathway | np | 20493818 | |
| Adiposity regulation (1) | eIF3-S8 | none | -1 | 20074523 | |
| Adiposity regulation (1) | eIF3-S8 | none | 0.136 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | eIF3-S8 | Decreased ERK phosphorylation after EGF stimulation | -3.81 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF3-S8 | Decreased ERK phosphorylation after EGF stimulation | -3.28 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF3-S8 | none | 0.15 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF3-S8 | none | 1.03 | 30 minutes sSpitz stimulation | 22028469 |
| Wnt proteins secretion | eIF3-S8 | Upregulation of Wg pathway | 3.6 | 22094269 | |
| Hippo pathway regulation | eIF3-S8 | none | 1.36 | 23263283 |
