74 Pathways

• Adaptive Immune System,
• G1/S Transition,
• Degradation of beta-catenin by the destruction complex,
• Regulation of Apoptosis,
• Synthesis of DNA,
• Cross-presentation of soluble exogenous antigens (endosomes),
• Separation of Sister Chromatids,
• Cell Cycle, Mitotic,
• Antigen processing: Ubiquitination & Proteasome degradation,
• APC/C:Cdc20 mediated degradation of mitotic proteins,
• Autodegradation of Cdh1 by Cdh1:APC/C,
• Polo-like kinase mediated events,
• DNA Repair,
• SCF(Skp2)-mediated degradation of p27/p21,
• Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
• Cyclin A:Cdk2-associated events at S phase entry,
• SCF-beta-TrCP mediated degradation of Emi1,
• Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
• Cyclin E associated events during G1/S transition,
• Cyclin A/B1 associated events during G2/M transition,
• Switching of origins to a post-replicative state,
• Immune System,
• p53-Independent DNA Damage Response,
• Orc1 removal from chromatin,
• Regulation of activated PAK-2p34 by proteasome mediated degradation,
• G2/M Transition,
• Mitotic Anaphase,
• Antigen processing-Cross presentation,
• Regulation of DNA replication,
• Signaling by Wnt,
• G2/M DNA damage checkpoint,
• Mitotic M-M/G1 phases,
• Cell Cycle,
• Inactivation of APC/C via direct inhibition of the APC/C complex,
• Homologous recombination repair of replication-independent double-strand breaks,
• Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
• G2/M Checkpoints,
• Regulation of mitotic cell cycle,
• ER-Phagosome pathway,
• Double-Strand Break Repair,
• DNA Replication Pre-Initiation,
• Regulation of APC/C activators between G1/S and early anaphase,
• CDK-mediated phosphorylation and removal of Cdc6,
• Beta-catenin phosphorylation cascade,
• Downstream Signaling Events Of B Cell Receptor (BCR),
• Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
• S Phase,
• APC/C:Cdc20 mediated degradation of Cyclin B,
• Mitotic G1-G1/S phases,
• APC/C:Cdc20 mediated degradation of Securin,
• B Cell Activation,
• Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
• Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
• Mitotic G2-G2/M phases,
• APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
• Amplification of signal from the kinetochores,
• Signaling Pathways,
• M Phase,
• Mitotic Spindle Checkpoint,
• Activation of NF-kappaB in B Cells,
• G1/S DNA Damage Checkpoints,
• G2/M DNA replication checkpoint,
• Homologous Recombination Repair,
• Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
• DNA Replication,
• M/G1 Transition,
• Cell Cycle Checkpoints,
• Mitotic Metaphase and Anaphase,
• p53-Independent G1/S DNA damage checkpoint,
• Apoptosis,
• Removal of licensing factors from origins,
• Class I MHC mediated antigen processing & presentation,
• ATM mediated response to DNA double-strand break,
• APC/C-mediated degradation of cell cycle proteins