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GO Term : GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

1 Data Sets

Name URL
GO Annotation from FlyBase  

1 Ontology

Name
GO

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
CG9272   CG9272 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
  nth-1 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

16 Parents

Identifier Name
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0004520 endodeoxyribonuclease activity
GO:0004518 nuclease activity
GO:0004536 deoxyribonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016787 hydrolase activity
GO:0004519 endonuclease activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity

17 Relations

Relationship
Parent Term . Name

Parent Term . Identifier

Child Term . Name

Child Term . Identifier
is_a oxidized base lesion DNA N-glycosylase activity GO:0000702 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a catalytic activity GO:0003824 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016799 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a hydrolase activity GO:0016787 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a endodeoxyribonuclease activity GO:0004520 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a DNA N-glycosylase activity GO:0019104 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a lyase activity GO:0016829 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a hydrolase activity, acting on ester bonds GO:0016788 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a hydrolase activity, acting on glycosyl bonds GO:0016798 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a endonuclease activity GO:0004519 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a molecular_function GO:0003674 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a nuclease activity GO:0004518 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a deoxyribonuclease activity GO:0004536 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a carbon-oxygen lyase activity GO:0016835 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
is_a oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703 5-formyluracil DNA N-glycosylase activity GO:0034042
is_a oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703 5-hydroxymethyluracil DNA N-glycosylase activity GO:0034043

9 Synonyms

Name Type
GO:0019004 alt_id
DNA glycosylase/AP-lyase broad_synonym
DNA glycosylase/beta-lyase broad_synonym
endodeoxyribonuclease III related_synonym
endonuclease VIII activity related_synonym
oxidized pyrimidine base lesion DNA N-glycosylase activity exact_synonym
bifunctional DNA glycosylase broad_synonym
endonuclease III related_synonym
pyrimidine-specific oxidized base lesion DNA N-glycosylase activity related_synonym