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GO Term : GO:0016236 macroautophagy GO

Namespace  biological_process Obsolete  false
description  The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

1 Data Sets

Name URL
GO Annotation from FlyBase  

1 Ontology

Name
GO

10 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
CG1643 Autophagy-specific gene 5 Atg5 GO:0016236 macroautophagy
CG5489 Autophagy-specific gene 7 Atg7 GO:0016236 macroautophagy
CG7986 Autophagy-specific gene 18 Atg18 GO:0016236 macroautophagy
CG10861 Autophagy-specific gene 12 Atg12 GO:0016236 macroautophagy
CG1347   Atg17 GO:0016236 macroautophagy
CG12334 Autophagy-specific gene 8b Atg8b GO:0016236 macroautophagy
CG1241 Autophagy-specific gene 2 Atg2 GO:0016236 macroautophagy
CG32672 Autophagy-specific gene 8a Atg8a GO:0016236 macroautophagy
CG9746 immune response deficient 1 ird1 GO:0016236 macroautophagy
CG10967 Autophagy-specific gene 1 Atg1 GO:0016236 macroautophagy

25 Parents

Identifier Name
GO:0044699 single-organism process
GO:0009987 cellular process
GO:0008150 biological_process
GO:0044763 single-organism cellular process
GO:0006950 response to stress
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
GO:0044237 cellular metabolic process
GO:0033554 cellular response to stress
GO:0044710 single-organism metabolic process
GO:0008152 metabolic process
GO:0009056 catabolic process
GO:0044712 single-organism catabolic process
GO:0016236 macroautophagy
GO:0044248 cellular catabolic process
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031667 response to nutrient levels
GO:0009605 response to external stimulus
GO:0071496 cellular response to external stimulus
GO:0006914 autophagy
GO:0007154 cell communication
GO:0009991 response to extracellular stimulus
GO:0042594 response to starvation
GO:0009267 cellular response to starvation

50 Relations

Relationship
Parent Term . Name

Parent Term . Identifier

Child Term . Name

Child Term . Identifier
part_of macroautophagy GO:0016236 autophagic vacuole assembly GO:0000045
part_of macroautophagy GO:0016236 autophagic vacuole fusion GO:0000046
is_a macroautophagy GO:0016236 macromitophagy GO:0000423
is_a macroautophagy GO:0016236 macropexophagy GO:0000425
is_a cellular response to starvation GO:0009267 macroautophagy GO:0016236
is_a autophagy GO:0006914 macroautophagy GO:0016236
is_a single-organism catabolic process GO:0044712 macroautophagy GO:0016236
is_a response to extracellular stimulus GO:0009991 macroautophagy GO:0016236
is_a cellular response to nutrient levels GO:0031669 macroautophagy GO:0016236
is_a biological_process GO:0008150 macroautophagy GO:0016236
is_a cellular response to extracellular stimulus GO:0031668 macroautophagy GO:0016236
is_a response to nutrient levels GO:0031667 macroautophagy GO:0016236
is_a catabolic process GO:0009056 macroautophagy GO:0016236
is_a metabolic process GO:0008152 macroautophagy GO:0016236
is_a single-organism process GO:0044699 macroautophagy GO:0016236
is_a cell communication GO:0007154 macroautophagy GO:0016236
is_a cellular process GO:0009987 macroautophagy GO:0016236
is_a response to starvation GO:0042594 macroautophagy GO:0016236
is_a cellular catabolic process GO:0044248 macroautophagy GO:0016236
is_a cellular response to external stimulus GO:0071496 macroautophagy GO:0016236
is_a cellular response to stimulus GO:0051716 macroautophagy GO:0016236
is_a response to external stimulus GO:0009605 macroautophagy GO:0016236
is_a cellular response to stress GO:0033554 macroautophagy GO:0016236
is_a response to stress GO:0006950 macroautophagy GO:0016236
is_a cellular metabolic process GO:0044237 macroautophagy GO:0016236
is_a single-organism metabolic process GO:0044710 macroautophagy GO:0016236
is_a single-organism cellular process GO:0044763 macroautophagy GO:0016236
is_a response to stimulus GO:0050896 macroautophagy GO:0016236
positively regulates macroautophagy GO:0016236 positive regulation of macroautophagy GO:0016239
regulates macroautophagy GO:0016236 positive regulation of macroautophagy GO:0016239

4 Synonyms

Name Type
non-specific autophagy exact_synonym
autophagy in response to cellular starvation exact_synonym
GO:0034262 alt_id
starvation-induced autophagy exact_synonym