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Protein Domain : IPR020420

Name	Atypical dual specificity phosphatase, subfamily B	Short Name	Atypical_DUSP_famB
Type	Family	Description	Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [, ]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. In general, DUSPs are classified into the following subgroups []:Slingshot phosphatasesPhosphatase of regenerating liver (PRL)Cdc14 phosphatasesPhosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatasesMitogen-activated protein kinase phosphatases (MKPs)Atypical DUSPsThe atypical DUSPs share a high degree of similarity with the MKP subgroup, but lack the N-terminal regulatory domain, which provides the substrate specificity towards the MAP kinases. These atypical-DUSPs form a heterogeneous group and have in common the presence of a single catalytic PTP domain. VHR was the first characterised member of this subfamily; its crystal structure is known [, ].The function of many atypical DUSPs remains unknown, although some have been related to regulation of MAP kinase pathways [, , ]. VHR has also been related to the control of cell-senescence []. The atypical DUSPs can be subdivided into two groups (termed A and B) on the basis of sequence similarity. Each of these subgroups is characterised by its own distinctive set of motifs, the functions of which are as yet unknown.This entry also includes DUSP1 which does not belong to the atypical DUSP family.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier	Name	Short Name	Type
IPR000387	Protein-tyrosine/Dual specificity phosphatase	Tyr/Dual-sp_Pase	Domain
IPR016130	Protein-tyrosine phosphatase, active site	Tyr_Pase_AS	Active_site
IPR000340	Dual specificity phosphatase, catalytic domain	Dual-sp_phosphatase_cat-dom	Domain
IPR020422	Dual specificity phosphatase, subgroup, catalytic domain	Dual-sp_phosphatase_subgr_cat	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PR01910	PRINTS	IPR020420

2 Data Sets

Name	URL
InterPro data set
InterPro GO Annotation data set

0 Found In

1 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Atypical dual specificity phosphatase, subfamily B		GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

1 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Atypical dual specificity phosphatase, subfamily B		GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

1 Parent Features

DB identifier	Name	Short Name	Type
IPR020417	Atypical dual specificity phosphatase	Atypical_DUSP	Family

0 Proteins

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