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Protein Domain : IPR020420

Name  Atypical dual specificity phosphatase, subfamily B Short Name  Atypical_DUSP_famB
Type  Family Description  Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [, ]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. In general, DUSPs are classified into the following subgroups []:Slingshot phosphatasesPhosphatase of regenerating liver (PRL)Cdc14 phosphatasesPhosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatasesMitogen-activated protein kinase phosphatases (MKPs)Atypical DUSPsThe atypical DUSPs share a high degree of similarity with the MKP subgroup, but lack the N-terminal regulatory domain, which provides the substrate specificity towards the MAP kinases. These atypical-DUSPs form a heterogeneous group and have in common the presence of a single catalytic PTP domain. VHR was the first characterised member of this subfamily; its crystal structure is known [, ].The function of many atypical DUSPs remains unknown, although some have been related to regulation of MAP kinase pathways [, , ]. VHR has also been related to the control of cell-senescence []. The atypical DUSPs can be subdivided into two groups (termed A and B) on the basis of sequence similarity. Each of these subgroups is characterised by its own distinctive set of motifs, the functions of which are as yet unknown.This entry also includes DUSP1 which does not belong to the atypical DUSP family.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR016130 Protein-tyrosine phosphatase, active site Tyr_Pase_AS Active_site
IPR000340 Dual specificity phosphatase, catalytic domain Dual-sp_phosphatase_cat-dom Domain
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain Dual-sp_phosphatase_subgr_cat Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR01910 PRINTS IPR020420

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Atypical dual specificity phosphatase, subfamily B   GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Atypical dual specificity phosphatase, subfamily B   GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity

1 Parent Features

DB identifier Name Short Name Type
IPR020417 Atypical dual specificity phosphatase Atypical_DUSP Family

0 Proteins