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Protein Domain : IPR012052

Name  Sporulation transcription factor Spo0A Short Name  Spore_0_A
Type  Family Description  Members of this group are response regulators/transcription factors that contain CheY-like receiver (phosphoacceptor) domain and a unique DNA-binding domain. Spo0A controls the entry of Bacillus subtilisinto the developmental process of sporulation []. Activation of the Spo0A transcription factor by phosphorylation serves as a developmental checkpoint and to integrate several physiological signals that control entry into the sporulation pathway. The signals are generated by conditions of nutrient deprivation, high cell density, the Krebs cycle, DNA replication, DNA damage, and some aspect of the chromosome partitioning machinery [].Activated Spo0A has multiple functions []. It represses promoters (such as the abrB promoter) by binding to sites (0A boxes) downstream from the transcription start site. Spo0A also activates transcription from promoters used by two forms of RNA polymerase that differ by containing either the major sigma factor, sigma A (e.g. the spoIIE and spoIIG promoters) or the alternate sigma factor, sigma H (e.g. the spoIIA promoter). At promoters activated by Spo0A, the 0A boxes lie upstream of the transcription-initiation site.

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR014879 Sporulation initiation factor Spo0A, C-terminal Spo0A_C Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF002937 PIRSF IPR012052
TIGR02875 TIGRFAMs IPR012052

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

5 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sporulation transcription factor Spo0A   GO:0003677 DNA binding
Sporulation transcription factor Spo0A   GO:0005509 calcium ion binding
Sporulation transcription factor Spo0A   GO:0006355 regulation of transcription, DNA-templated
Sporulation transcription factor Spo0A   GO:0043937 regulation of sporulation
Sporulation transcription factor Spo0A   GO:0051606 detection of stimulus

5 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Sporulation transcription factor Spo0A   GO:0003677 DNA binding
Sporulation transcription factor Spo0A   GO:0005509 calcium ion binding
Sporulation transcription factor Spo0A   GO:0006355 regulation of transcription, DNA-templated
Sporulation transcription factor Spo0A   GO:0043937 regulation of sporulation
Sporulation transcription factor Spo0A   GO:0051606 detection of stimulus

0 Parent Features

0 Proteins