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Protein Domain : IPR027133

Name  TNF receptor-associated factor 2 Short Name  TRAF2
Type  Family Description  TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10131:SF21 PANTHER IPR027133

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

6 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 2   GO:0004842 ubiquitin-protein transferase activity
TNF receptor-associated factor 2   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 2   GO:0033209 tumor necrosis factor-mediated signaling pathway
TNF receptor-associated factor 2   GO:0042981 regulation of apoptotic process
TNF receptor-associated factor 2   GO:0046328 regulation of JNK cascade
TNF receptor-associated factor 2   GO:0051865 protein autoubiquitination

6 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 2   GO:0004842 ubiquitin-protein transferase activity
TNF receptor-associated factor 2   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 2   GO:0033209 tumor necrosis factor-mediated signaling pathway
TNF receptor-associated factor 2   GO:0042981 regulation of apoptotic process
TNF receptor-associated factor 2   GO:0046328 regulation of JNK cascade
TNF receptor-associated factor 2   GO:0051865 protein autoubiquitination

1 Parent Features

DB identifier Name Short Name Type
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family

0 Proteins