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Protein Domain : IPR016336

Name	Receptor tyrosine-protein phosphatase, alpha/epsilon-type	Short Name	Tyr_Pase_rcpt_a/e-type
Type	Family	Description	This entry represents receptor tyrosine-protein phosphatases (PTP) (), including both alpha type and epsilon type. PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity []. PTP-epsilon is a negative regulator of insulin signalling, where the cytosolic form has been shown to act in skeletal muscle []and the receptor-type enzyme has been shown to act in primary hepatocytes and liver [].

Publication Counts Displayer

1 Child Features

DB identifier	Name	Short Name	Type
IPR027262	Receptor tyrosine-protein phosphatase alpha	Tyr_Pase_rcpt_alpha	Family

2 Contains

DB identifier	Name	Short Name	Type
IPR000387	Protein-tyrosine/Dual specificity phosphatase	Tyr/Dual-sp_Pase	Domain
IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type	Tyr_Pase_rcpt/non-rcpt	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PIRSF002006	PIRSF	IPR016336

2 Data Sets

Name	URL
InterPro data set
InterPro GO Annotation data set

0 Found In

2 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Receptor tyrosine-protein phosphatase, alpha/epsilon-type		GO:0004725	protein tyrosine phosphatase activity
	Receptor tyrosine-protein phosphatase, alpha/epsilon-type		GO:0006470	protein dephosphorylation

2 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Receptor tyrosine-protein phosphatase, alpha/epsilon-type		GO:0004725	protein tyrosine phosphatase activity
	Receptor tyrosine-protein phosphatase, alpha/epsilon-type		GO:0006470	protein dephosphorylation

0 Parent Features

0 Proteins

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