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Protein Domain : IPR016336

Name  Receptor tyrosine-protein phosphatase, alpha/epsilon-type Short Name  Tyr_Pase_rcpt_a/e-type
Type  Family Description  This entry represents receptor tyrosine-protein phosphatases (PTP) (), including both alpha type and epsilon type. PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity []. PTP-epsilon is a negative regulator of insulin signalling, where the cytosolic form has been shown to act in skeletal muscle []and the receptor-type enzyme has been shown to act in primary hepatocytes and liver [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR027262 Receptor tyrosine-protein phosphatase alpha Tyr_Pase_rcpt_alpha Family

2 Contains

DB identifier Name Short Name Type
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type Tyr_Pase_rcpt/non-rcpt Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF002006 PIRSF IPR016336

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Receptor tyrosine-protein phosphatase, alpha/epsilon-type   GO:0004725 protein tyrosine phosphatase activity
Receptor tyrosine-protein phosphatase, alpha/epsilon-type   GO:0006470 protein dephosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Receptor tyrosine-protein phosphatase, alpha/epsilon-type   GO:0004725 protein tyrosine phosphatase activity
Receptor tyrosine-protein phosphatase, alpha/epsilon-type   GO:0006470 protein dephosphorylation

0 Parent Features

0 Proteins