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Protein Domain : IPR006291

Name  Signal transduction response regulator, heavy metal response Short Name  Sig_transdc_resp-reg_metal
Type  Family Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents a response regulator receiver domain and an associated transcriptional regulatory region. This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members are encoded by genes adjacent to genes which code for a member of the heavy metal sensor histidine kinase family (), its partner in the two-component response regulator system.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR001867 Signal transduction response regulator, C-terminal Sig_transdc_resp-reg_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
TIGR01387 TIGRFAMs IPR006291

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, heavy metal response   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, heavy metal response   GO:0003677 DNA binding
Signal transduction response regulator, heavy metal response   GO:0000160 phosphorelay signal transduction system

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, heavy metal response   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, heavy metal response   GO:0003677 DNA binding
Signal transduction response regulator, heavy metal response   GO:0000160 phosphorelay signal transduction system

0 Parent Features

0 Proteins