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Protein Domain : IPR011879

Name  Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB Short Name  Sig_transdc_resp-reg_PhoB
Type  Family Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents the signal transduction regulatory protein PhoB. PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself []. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; ) and presumably regulates these as well.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR001867 Signal transduction response regulator, C-terminal Sig_transdc_resp-reg_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
TIGR02154 TIGRFAMs IPR011879

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0003677 DNA binding
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0000160 phosphorelay signal transduction system
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0006817 phosphate ion transport

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0003677 DNA binding
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0000160 phosphorelay signal transduction system
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB   GO:0006817 phosphate ion transport

0 Parent Features

0 Proteins