modENCODE |  Help |  blog

Protein Domain : IPR017405

Name  Citron Rho-interacting kinase Short Name  Citron_Rho-interacting_kinase
Type  Family Description  Citron Rho-interacting kinase (CRIK) is a dual specificity protein kinase, which catalyses the autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues []. It plays an important role in the regulation of cytokinesis and the development of the central nervous system. It is required for KIF14 localization to the central spindle and mid-body. It is also a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. This protein occurs in at least two different isoforms: CRIK (about 240kDa), in which the kinase domain is followed by the sequence of Citron (a Rho/Rac binding protein); and CRIK-short kinase (CRIK-SK, about 54kDa), which consists mostly of the kinase domain. CRIK may fulfil more specialised functions in specific cell types [].

Publication Counts Displayer

0 Child Features

8 Contains

DB identifier Name Short Name Type
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding Prot_Kinase_C-like_PE/DAG-bd Domain
IPR017892 Protein kinase, C-terminal Pkinase_C Domain
IPR001180 Citron-like Citron Domain

1 Cross References

Source . Name

Subject . Primary Identifier
PIRSF038145 PIRSF IPR017405

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins