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Protein Domain : IPR014285

Name  Nitrogen fixation negative regulator NifL Short Name  N_fixation_neg-reg_NifL
Type  Family Description  NifL fromAzotobacter vinelandiisenses both the redox and fixed nitrogen status to regulate nitrogen fixation. NifL acts by modulating the activity of the nitrogen fixation positive regulator protein NifA: NifL inhibits NifA in response to oxygen and low level of fixed nitrogen. NifA and NifL are encoded by adjacent genes. NifL is FAD-containing, and has a domain architecture similar to that of the cytoplasmic histidine protein kinases, containing two N-terminal PAS domains and a C-terminal transmitter region containing a conserved histidine residue (H domain) and a nucleotide binding GHKL domain corresponding to the catalytic core of the histidine kinases []. However, NifL does not exhibit kinase activity and regulates its partner NifA by direct protein-protein interactions rather than phosphorylation.

Publication Counts Displayer

0 Child Features

7 Contains

DB identifier Name Short Name Type
IPR001610 PAC motif PAC Repeat
IPR000014 PAS domain PAS Domain
IPR003594 Histidine kinase-like ATPase, ATP-binding domain HATPase_ATP-bd Domain
IPR000700 PAS-associated, C-terminal PAS-assoc_C Domain
IPR013767 PAS fold PAS_fold Domain
IPR005467 Signal transduction histidine kinase, core Sig_transdc_His_kinase_core Domain
IPR004358 Signal transduction histidine kinase-related protein, C-terminal Sig_transdc_His_kin-like_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
TIGR02938 TIGRFAMs IPR014285

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Nitrogen fixation negative regulator NifL   GO:0004871 signal transducer activity
Nitrogen fixation negative regulator NifL   GO:0050660 flavin adenine dinucleotide binding
Nitrogen fixation negative regulator NifL   GO:0007165 signal transduction
Nitrogen fixation negative regulator NifL   GO:0009399 nitrogen fixation

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Nitrogen fixation negative regulator NifL   GO:0004871 signal transducer activity
Nitrogen fixation negative regulator NifL   GO:0050660 flavin adenine dinucleotide binding
Nitrogen fixation negative regulator NifL   GO:0007165 signal transduction
Nitrogen fixation negative regulator NifL   GO:0009399 nitrogen fixation

0 Parent Features

0 Proteins