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Protein Domain : IPR014402

Name  Transcription factor, Skn7-like Short Name  Sig_transdc_resp-reg_Skn7
Type  Family Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents transcription factor, Skn7 type, including Skn7 from budding yeast and Prr1 from fission yeast [, , ].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR027718 Transcription factor Skn7 TF_Skn7 Family

1 Contains

DB identifier Name Short Name Type
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF002595 PIRSF IPR014402

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

6 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor, Skn7-like   GO:0000156 phosphorelay response regulator activity
Transcription factor, Skn7-like   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription factor, Skn7-like   GO:0000160 phosphorelay signal transduction system
Transcription factor, Skn7-like   GO:0006355 regulation of transcription, DNA-templated
Transcription factor, Skn7-like   GO:0006950 response to stress
Transcription factor, Skn7-like   GO:0005634 nucleus

6 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor, Skn7-like   GO:0000156 phosphorelay response regulator activity
Transcription factor, Skn7-like   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription factor, Skn7-like   GO:0000160 phosphorelay signal transduction system
Transcription factor, Skn7-like   GO:0006355 regulation of transcription, DNA-templated
Transcription factor, Skn7-like   GO:0006950 response to stress
Transcription factor, Skn7-like   GO:0005634 nucleus

1 Parent Features

DB identifier Name Short Name Type
IPR027725 Heat shock transcription factor family HSF_fam Family

0 Proteins