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Protein Domain : IPR005477

Name  Deoxyxylulose-5-phosphate synthase Short Name  Dxylulose-5-P_synthase
Type  Family Description  DXP synthase is a thiamine diphosphate-dependent enzyme related to transketolase andthe pyruvate dehydrogenase E1-beta subunit. DXP synthase is found in bacteria (gene dxs)and plants (gene CLA1) which catalyzes the thiamine pyrophosphoate-dependent acyloin condensation reaction betweencarbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (dxp), aprecursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6). DXP synthase isevolutionary related to TK. The N-terminal section, contains a histidine residue which appears to function in proton transferduring catalysis []. In the central section there are conserved acidic residues that are part of the active cleftand may participate in substrate-binding []. This family includes transketolase enzymes . and alsopartially matches to 2-oxoisovalerate dehydrogenase beta subunit P37941 . Both these enzymes utilise thiaminepyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR005475 Transketolase-like, pyrimidine-binding domain Transketolase-like_Pyr-bd Domain
IPR020826 Transketolase binding site Transketolase_BS Binding_site
IPR005476 Transketolase, C-terminal Transketolase_C Domain
IPR005474 Transketolase, N-terminal Transketolase_N Domain

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF13292 PFAM IPR005477
TIGR00204 TIGRFAMs IPR005477
MF_00315 HAMAP IPR005477

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Deoxyxylulose-5-phosphate synthase   GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Deoxyxylulose-5-phosphate synthase   GO:0016114 terpenoid biosynthetic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Deoxyxylulose-5-phosphate synthase   GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Deoxyxylulose-5-phosphate synthase   GO:0016114 terpenoid biosynthetic process

0 Parent Features

0 Proteins