modENCODE |  Help |  blog

Protein Domain : IPR022308

Name  Synaptic vesicle protein SV2 Short Name  SV2
Type  Family Description  SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor isoform (SV2C) that resemble transporter proteins. SV2B knockout mice are phenotypically normal while SV2A- and SV2A/SV2Bdouble knockout mice exhibit severe seizures and die postnatally. Without SV2 proteins, presynaptic Ca2+accumulation during consecutive action potentials causes abnormal increases in neurotransmitter release that destabilise synaptic circuits and induce epilepsy [].

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR020846 Major facilitator superfamily domain MFS_dom Domain
IPR016196 Major facilitator superfamily domain, general substrate transporter MFS_dom_general_subst_transpt Domain
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR24065 PANTHER IPR022308
TIGR01299 TIGRFAMs IPR022308

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Synaptic vesicle protein SV2   GO:0005215 transporter activity
Synaptic vesicle protein SV2   GO:0006810 transport
Synaptic vesicle protein SV2   GO:0016020 membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Synaptic vesicle protein SV2   GO:0005215 transporter activity
Synaptic vesicle protein SV2   GO:0006810 transport
Synaptic vesicle protein SV2   GO:0016020 membrane

1 Parent Features

DB identifier Name Short Name Type
IPR011701 Major facilitator superfamily MFS Family

0 Proteins