| Name | Talin-2 | Short Name | Talin-2 |
| Type | Family | Description | Talin is a large cytoskeletal protein that forms an antiparallel homodimer, each with an N-terminal globular head and a larger C-terminal rod. The head domain contains a FERM (4.1, ezrin, radixin, moesin) domain, which has been implicated in both integrin and actin-binding. Binding of integrin beta cytoplasmic tails to the FERM domain has been found to induce integrinactivation []. The rod domain also appears to mediate binding to both actin and integrins []. The C-terminal rod contains an I/LWEQ domain. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin []. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [].In vivo, talin has been shown to play a critical role in the formation of cell adhesions and regulation of integrin signalling in numerous species []. Talin localises to some neuromuscular junction and sites of cell-cell adhesions, as well as to focal adhesions, sites of attachment to the substratum.This entry represents talin-2. |
| DB identifier | Name | Short Name | Type |
|---|---|---|---|
| IPR011993 | Pleckstrin homology-like domain | PH_like_dom | Domain |
| IPR019749 | Band 4.1 domain | Band_41_domain | Domain |
| IPR019748 | FERM central domain | FERM_central | Domain |
| IPR000299 | FERM domain | FERM_domain | Domain |
| IPR018979 | FERM, N-terminal | FERM_N | Domain |
| IPR002558 | I/LWEQ domain | ILWEQ_dom | Domain |
| IPR015009 | Vinculin-binding site-containing domain | Vinculin-bd_dom | Domain |
