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Protein Domain : IPR015711

Name  Talin-2 Short Name  Talin-2
Type  Family Description  Talin is a large cytoskeletal protein that forms an antiparallel homodimer, each with an N-terminal globular head and a larger C-terminal rod. The head domain contains a FERM (4.1, ezrin, radixin, moesin) domain, which has been implicated in both integrin and actin-binding. Binding of integrin beta cytoplasmic tails to the FERM domain has been found to induce integrinactivation []. The rod domain also appears to mediate binding to both actin and integrins []. The C-terminal rod contains an I/LWEQ domain. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin []. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [].In vivo, talin has been shown to play a critical role in the formation of cell adhesions and regulation of integrin signalling in numerous species []. Talin localises to some neuromuscular junction and sites of cell-cell adhesions, as well as to focal adhesions, sites of attachment to the substratum.This entry represents talin-2.

Publication Counts Displayer

0 Child Features

7 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR002558 I/LWEQ domain ILWEQ_dom Domain
IPR015009 Vinculin-binding site-containing domain Vinculin-bd_dom Domain

1 Cross References

Source . Name

Subject . Primary Identifier
PTHR19981:SF15 PANTHER IPR015711

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins