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Protein Domain : IPR015710

Name  Talin-1 Short Name  Talin-1
Type  Family Description  Talin is a large cytoskeletal protein that forms an antiparallel homodimer, each with an N-terminal globular head and a larger C-terminal rod. The head domain contains a FERM (4.1, ezrin, radixin, moesin) domain, which has been implicated in both integrin and actin-binding. Binding of integrin beta cytoplasmic tails to the FERM domain has been found to induce integrin activation []. The rod domain also appears to mediate binding to both actin and integrins []. The C-terminal rod contains an I/LWEQ domain. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin []. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [].In vivo, talin has been shown to play a critical role in the formation of cell adhesions and regulation of integrin signalling in numerous species []. It is probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin localises to some neuromuscular junction and sites of cell-cell adhesions, as well as to focal adhesions, sites of attachment to the substratum. Filopodin, a homologue of talin, was identified in the slime mold Dictyostelium discoideum(Slime mold).This entry represents talin-1.

Publication Counts Displayer

0 Child Features

8 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR002558 I/LWEQ domain ILWEQ_dom Domain
IPR015224 Talin, central Talin_cent Domain
IPR015009 Vinculin-binding site-containing domain Vinculin-bd_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR19981:SF7 PANTHER IPR015710

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Talin-1   GO:0007016 cytoskeletal anchoring at plasma membrane

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Talin-1   GO:0007016 cytoskeletal anchoring at plasma membrane

0 Parent Features

0 Proteins