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Protein Domain : IPR012153

Name  Protein-tyrosine phosphatase, non-receptor type-13 Short Name  Tyr_Pase_non-rcpt_typ-13
Type  Family Description  Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. This entry represents non-receptor PTPase type 13 (also known as PTPL1, FAP-1 and PTP-BL). Studies indicate that this PTPase is involved in multiple regulatory functions including: negative regulation of FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling, regulation of the phophorylation status of ephrinB receptors in neurons, regulation of cytokinesis in epithelial cells, and the regulation of negative proliferation signals in breast cancer cells [, , , ]. This protein has been shown to interact with a wide variety of partners, an ability conferred by the presence of five distinct PDZ domains, and is thus suggested to function as an integrator between different signalling pathways. Multiple isoforms of this protein are formed by alternative splicing, which can dramatically affect its protein binding characteristics [].

Publication Counts Displayer

0 Child Features

10 Contains

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR019748 FERM central domain FERM_central Domain
IPR000299 FERM domain FERM_domain Domain
IPR018979 FERM, N-terminal FERM_N Domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type Tyr_Pase_rcpt/non-rcpt Domain
IPR001478 PDZ domain PDZ Domain
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain
IPR011019 KIND KIND Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR19134:SF197 PANTHER IPR012153
PIRSF000933 PIRSF IPR012153

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, non-receptor type-13   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, non-receptor type-13   GO:0006470 protein dephosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, non-receptor type-13   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, non-receptor type-13   GO:0006470 protein dephosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR019750 Band 4.1 family Band_41_fam Family

0 Proteins