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Protein Domain : IPR014392

Name	Protein-tyrosine phosphatase, non-receptor type-14, -21	Short Name	Tyr_Pase_non-rcpt_typ-14/21
Type	Family	Description	Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. This entry represents a tyrosine-protein phosphatase, non-receptor types 14 and 21.

Publication Counts Displayer

0 Child Features

10 Contains

DB identifier	Name	Short Name	Type
IPR011993	Pleckstrin homology-like domain	PH_like_dom	Domain
IPR019749	Band 4.1 domain	Band_41_domain	Domain
IPR019748	FERM central domain	FERM_central	Domain
IPR000299	FERM domain	FERM_domain	Domain
IPR018979	FERM, N-terminal	FERM_N	Domain
IPR000387	Protein-tyrosine/Dual specificity phosphatase	Tyr/Dual-sp_Pase	Domain
IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type	Tyr_Pase_rcpt/non-rcpt	Domain
IPR016130	Protein-tyrosine phosphatase, active site	Tyr_Pase_AS	Active_site
IPR019747	FERM conserved site	FERM_CS	Conserved_site
IPR018980	FERM, C-terminal PH-like domain	FERM_PH-like_C	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PIRSF000934	PIRSF	IPR014392

2 Data Sets

Name	URL
InterPro data set
InterPro GO Annotation data set

0 Found In

2 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Protein-tyrosine phosphatase, non-receptor type-14, -21		GO:0004725	protein tyrosine phosphatase activity
	Protein-tyrosine phosphatase, non-receptor type-14, -21		GO:0006470	protein dephosphorylation

2 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Protein-tyrosine phosphatase, non-receptor type-14, -21		GO:0004725	protein tyrosine phosphatase activity
	Protein-tyrosine phosphatase, non-receptor type-14, -21		GO:0006470	protein dephosphorylation

1 Parent Features

DB identifier	Name	Short Name	Type
IPR019750	Band 4.1 family	Band_41_fam	Family

0 Proteins

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