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Protein Domain : IPR009219

Name  Bacteriophytochrome, CheY-like Short Name  Bactrphtchr_CheY
Type  Family Description  This entry contains bacteriophytochromes, or BphPs (light-regulated signal transduction histidine kinases) with the receiver (CheY-like) domain fused at the C terminus.Phytochrome dimeric photoreceptors regulate growth and development by sensing ambient light []. Apart from phytochromes in photosynthetic organisms, phytochrome-like photoreceptors have been found in several nonphotosynthetic organisms, including in the heterotrophic eubacteria Deinococcus radioduransand Pseudomonas aeruginosa, ]. These homodimeric photoreceptors sense red light (R) and far-red light (FR) through photointerconversion between two stable conformations, a R-absorbing Pr form and a FR-absorbing Pfr form [].Phytochromes in general contain a signature N-terminal chromophore-binding region (CBD) that includes GAF and PHY domains, both of which are essential for autocatalytically binding bilin chromophores. A C-terminal module is involved in signal transduction and homodimerisation, and is different in different groups of phytochromes. Phytochromes are divided into three groups: plant phys, cyanobacterial phys (Cphs), and bacteriophytochrome photoreceptors (BphPs) [].The BphPs are common among photosynthetic and nonphotosynthetic Eubacteria and present in some fungi []. They act as photoregulated kinases that presumably initiate the phosphorelay cascade by phosphotransfer to an associated response regulator (RR). In some cases, the receiver (CheY-like) domain of this RR is fused to the C-terminal end of the BphP (such hybrid proteins are in this entry).Like Cphs, BphPs often contain the canonical two-component histidine kinase motif and act as histidine kinases in vitro. The main distinction is that they use the bilin biliverdin (BV) as the chromophore []. Included in the CBD are the positionally conserved cysteine (Cys-20 and Cys-13) and histidine (His-250 and His-248) residues that could serve as the chromophore-binding site, by using either a thiolether or Schiff-base-type linkage, respectively [, , , ].

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR011102 Signal transduction histidine kinase, HWE region Sig_transdc_His_kinase_HWE Domain
IPR016132 Phytochrome chromophore attachment domain Phyto_chromo_attachment Domain
IPR013654 PAS fold-2 PAS_2 Domain

1 Cross References

Source . Name

Subject . Primary Identifier
PIRSF036397 PIRSF IPR009219

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR001294 Phytochrome Phytochrome Family

0 Proteins