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Pathway : 77132 NRAGE signals death through JNK

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

17 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0023172 CG9635 RhoGEF2 Rho guanine nucleotide exchange factor 2 FlyBase D. melanogaster
FBgn0025836 CG40494 RhoGAP1A Rho GTPase activating protein at 1A FlyBase D. melanogaster
FBgn0014011 CG8556 Rac2 Rac2 FlyBase D. melanogaster
FBgn0010333 CG2248 Rac1 Rac1 FlyBase D. melanogaster
FBgn0023388 CG1099 Dap160 Dynamin associated protein 160 FlyBase D. melanogaster
FBgn0024277 CG18214 trio trio FlyBase D. melanogaster
FBgn0000229 CG5680 bsk basket FlyBase D. melanogaster
FBgn0050115 CG30115 GEFmeso Guanine nucleotide exchange factor in mesoderm FlyBase D. melanogaster
FBgn0262562 CG43102 CG43102 FlyBase D. melanogaster
FBgn0003041 CG8114 pbl pebble FlyBase D. melanogaster
FBgn0264707 CG43976 RhoGEF3 Rho guanine nucleotide exchange factor 3 FlyBase D. melanogaster
FBgn0261547 CG42665 Exn Ephexin FlyBase D. melanogaster
FBgn0032796 CG10188 CG10188 FlyBase D. melanogaster
FBgn0085447 CG34418 sif still life FlyBase D. melanogaster
FBgn0001965 CG7793 Sos Son of sevenless FlyBase D. melanogaster
FBgn0261556 CG42674 CG42674 FlyBase D. melanogaster
FBgn0050440 CG30440 CG30440 FlyBase D. melanogaster

80 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0072614 P40792 Drosophila melanogaster
FBpp0080821 Q9VIV0 Drosophila melanogaster
FBpp0306076 Q8IRJ3 Drosophila melanogaster
FBpp0079676 P92208 Drosophila melanogaster
FBpp0305023 P48554 Drosophila melanogaster
FBpp0072543 Q8IRI4 Drosophila melanogaster
FBpp0072540 Q7KVD1 Drosophila melanogaster
FBpp0089283 Q7YZA0 Drosophila melanogaster
FBpp0072541 Q8IRI5 Drosophila melanogaster
FBpp0306082 E1JHV3 Drosophila melanogaster
FBpp0306081 Q9W0S0 Drosophila melanogaster
FBpp0081031 Q9VIF7 Drosophila melanogaster
FBpp0081032 Q8INU2 Drosophila melanogaster
FBpp0085412 Q7K4E0 Drosophila melanogaster
FBpp0080118 P26675 Drosophila melanogaster
FBpp0076486 Q9U7D8 Drosophila melanogaster
FBpp0076489 Q8IQ95 Drosophila melanogaster
FBpp0076487 Q8IQ97 Drosophila melanogaster
FBpp0076488 Q8IQ96 Drosophila melanogaster
FBpp0289650 A1ZBA1 Drosophila melanogaster
FBpp0291788 Q9Y150 Drosophila melanogaster
FBpp0291791 Q9VVC6 Drosophila melanogaster
FBpp0111833 Q29QE1 Drosophila melanogaster
FBpp0309062 C1C560 Drosophila melanogaster
FBpp0309333 B3DN64 Drosophila melanogaster
FBpp0111622 P91620 Drosophila melanogaster
FBpp0111620 P91621 Drosophila melanogaster
FBpp0111729 A8JNN0 Drosophila melanogaster