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Pathway : 106235 Inhibition of replication initiation of damaged DNA by RB1/E2F1

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

5 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0011766 CG6376 E2f E2F transcription factor FlyBase D. melanogaster
FBgn0015799 CG7413 Rbf Retinoblastoma-family protein FlyBase D. melanogaster
FBgn0011762 CG7108 DNApol-alpha50 DNA polymerase alpha 50kD FlyBase D. melanogaster
FBgn0259113 CG6349 DNApol-alpha180 DNA polymerase alpha 180kD FlyBase D. melanogaster
FBgn0005696 CG5923 DNApol-alpha73 DNA polymerase alpha 73kD FlyBase D. melanogaster

5 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0083518 Q27368 Drosophila melanogaster
FBpp0070141 Q24472 Drosophila melanogaster
FBpp0076330 Q24317 Drosophila melanogaster
FBpp0083514 P26019 Drosophila melanogaster
FBpp0113035 Q9VB62 Drosophila melanogaster