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Pathway : 158569 A third proteolytic cleavage releases NICD

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

10 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0004647 CG3936 N Notch FlyBase D. melanogaster
FBgn0001168 CG6494 h hairy FlyBase D. melanogaster
FBgn0004837 CG3497 Su(H) Suppressor of Hairless FlyBase D. melanogaster
FBgn0019947 CG18803 Psn Presenilin FlyBase D. melanogaster
FBgn0031879 CG9138 uif uninflatable FlyBase D. melanogaster
FBgn0010109 CG8704 dpn deadpan FlyBase D. melanogaster
FBgn0266411 CG45051 sima similar FlyBase D. melanogaster
FBgn0053198 CG33198 pen-2 presenilin enhancer FlyBase D. melanogaster
FBgn0039234 CG7012 nct nicastrin FlyBase D. melanogaster
FBgn0031458 CG2855 aph-1 anterior pharynx defective 1 FlyBase D. melanogaster

15 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0288558 Q9VM55 Drosophila melanogaster
FBpp0291372 E1JHA6 Drosophila melanogaster
FBpp0077850 O02194 Drosophila melanogaster
FBpp0099504 P14003 Drosophila melanogaster
FBpp0307126 Q9VQG2 Drosophila melanogaster
FBpp0070483 P07207 Drosophila melanogaster
FBpp0084083 Q9VC27 Drosophila melanogaster
FBpp0080261 P28159 Drosophila melanogaster
FBpp0087879 Q26263 Drosophila melanogaster
FBpp0088783 Q86BE9 Drosophila melanogaster
FBpp0310747 Q24167 Drosophila melanogaster
A2VEG4_DROME A2VEG4 Drosophila melanogaster
Q9NGV4_DROME Q9NGV4 Drosophila melanogaster
B7Z036 Drosophila melanogaster
C0PVB0 Drosophila melanogaster