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Pathway : 162685 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

5 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0004647 CG3936 N Notch FlyBase D. melanogaster
FBgn0026176 CG8881 skpB skpB FlyBase D. melanogaster
FBgn0015509 CG1877 lin19 lin-19-like FlyBase D. melanogaster
FBgn0025638 CG16982 Roc1a Roc1a FlyBase D. melanogaster
FBgn0041171 CG15010 ago archipelago FlyBase D. melanogaster

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070483 P07207 Drosophila melanogaster
FBpp0073103 Q9VZF4 Drosophila melanogaster
FBpp0087921 Q24311 Drosophila melanogaster
FBpp0087127 Q7KJ69 Drosophila melanogaster
FBpp0070117 Q9W5E1 Drosophila melanogaster
C4XVM1_DROME C4XVM1 Drosophila melanogaster
O77430 Drosophila melanogaster