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Pathway : 162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

30 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0020388 CG4107 Gcn5 Gcn5 ortholog FlyBase D. melanogaster
FBgn0261617 CG15319 nej nejire FlyBase D. melanogaster
FBgn0000463 CG3619 Dl Delta FlyBase D. melanogaster
FBgn0004647 CG3936 N Notch FlyBase D. melanogaster
FBgn0263601 CG5841 mib1 mind bomb 1 FlyBase D. melanogaster
FBgn0015618 CG10572 Cdk8 Cyclin-dependent kinase 8 FlyBase D. melanogaster
FBgn0004597 CG7281 CycC Cyclin C FlyBase D. melanogaster
FBgn0259984 CG7147 kuz kuzbanian FlyBase D. melanogaster
FBgn0001168 CG6494 h hairy FlyBase D. melanogaster
FBgn0004837 CG3497 Su(H) Suppressor of Hairless FlyBase D. melanogaster
FBgn0002932 CG11988 neur neuralized FlyBase D. melanogaster
FBgn0019947 CG18803 Psn Presenilin FlyBase D. melanogaster
FBgn0026176 CG8881 skpB skpB FlyBase D. melanogaster
FBgn0004197 CG6127 Ser Serrate FlyBase D. melanogaster
FBgn0015509 CG1877 lin19 lin-19-like FlyBase D. melanogaster
FBgn0000524 CG3929 dx deltex FlyBase D. melanogaster
FBgn0010109 CG8704 dpn deadpan FlyBase D. melanogaster
FBgn0002973 CG3779 numb numb FlyBase D. melanogaster
FBgn0266411 CG45051 sima similar FlyBase D. melanogaster
FBgn0053198 CG33198 pen-2 presenilin enhancer FlyBase D. melanogaster
FBgn0039234 CG7012 nct nicastrin FlyBase D. melanogaster
FBgn0040206 CG1487 krz kurtz FlyBase D. melanogaster
FBgn0025638 CG16982 Roc1a Roc1a FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0041171 CG15010 ago archipelago FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0031458 CG2855 aph-1 anterior pharynx defective 1 FlyBase D. melanogaster
FBgn0004856 CG8264 Bx42 Bx42 FlyBase D. melanogaster
FBgn0003942 CG5271 RpS27A Ribosomal protein S27A FlyBase D. melanogaster
FBgn0003557 CG4244 Su(dx) Suppressor of deltex FlyBase D. melanogaster

49 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075275 Q9VUX2 Drosophila melanogaster
FBpp0077850 O02194 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0099504 P14003 Drosophila melanogaster
FBpp0100122 Q59DZ3 Drosophila melanogaster
FBpp0307126 Q9VQG2 Drosophila melanogaster
FBpp0083153 P10041 Drosophila melanogaster
FBpp0070483 P07207 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0073103 Q9VZF4 Drosophila melanogaster
FBpp0077495 Q9Y0H4 Drosophila melanogaster
FBpp0084083 Q9VC27 Drosophila melanogaster
FBpp0071285 P39736 Drosophila melanogaster
FBpp0076098 Q9VT57 Drosophila melanogaster
FBpp0087921 Q24311 Drosophila melanogaster
FBpp0080087 Q9VJW9 Drosophila melanogaster
FBpp0080261 P28159 Drosophila melanogaster
FBpp0071337 Q9W321 Drosophila melanogaster
FBpp0087879 Q26263 Drosophila melanogaster
FBpp0088783 Q86BE9 Drosophila melanogaster
FBpp0070876 Q23985 Drosophila melanogaster
FBpp0081481 P29503 Drosophila melanogaster
FBpp0082469 P25008 Drosophila melanogaster
FBpp0079420 P16554 Drosophila melanogaster
FBpp0085236 Q9V393 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0087127 Q7KJ69 Drosophila melanogaster
FBpp0075701 Q9VTZ1 Drosophila melanogaster
FBpp0309702 A8DZ03 Drosophila melanogaster
FBpp0290626 A8DZ02 Drosophila melanogaster