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Pathway : 172279 Loss of Function of SMAD2/3 in Cancer

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

34 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0005632 CG1945 faf fat facets FlyBase D. melanogaster
FBgn0034970 CG4005 yki yorkie FlyBase D. melanogaster
FBgn0015799 CG7413 Rbf Retinoblastoma-family protein FlyBase D. melanogaster
FBgn0011655 CG1775 Med Medea FlyBase D. melanogaster
FBgn0015618 CG10572 Cdk8 Cyclin-dependent kinase 8 FlyBase D. melanogaster
FBgn0004597 CG7281 CycC Cyclin C FlyBase D. melanogaster
FBgn0033749 CG8819 achi achintya FlyBase D. melanogaster
FBgn0031885 CG13778 Mnn1 Menin 1 FlyBase D. melanogaster
FBgn0020497 CG13387 emb embargoed FlyBase D. melanogaster
FBgn0010247 CG40411 Parp Poly-(ADP-ribose) polymerase FlyBase D. melanogaster
FBgn0025455 CG6292 CycT Cyclin T FlyBase D. melanogaster
FBgn0039169 CG5669 Spps Sp1-like factor for pairing sensitive-silencing FlyBase D. melanogaster
FBgn0025800 CG2262 Smox Smad on X FlyBase D. melanogaster
FBgn0265523 CG4013 Smr Smrter FlyBase D. melanogaster
FBgn0038197 CG3143 foxo forkhead box, sub-group O FlyBase D. melanogaster
FBgn0086361 CG1906 alph alphabet FlyBase D. melanogaster
FBgn0023097 CG5206 bon bonus FlyBase D. melanogaster
FBgn0020493 CG5201 Dad Daughters against dpp FlyBase D. melanogaster
FBgn0029006 CG4943 lack lethal with a checkpoint kinase FlyBase D. melanogaster
FBgn0085450 CG34421 Snoo Sno oncogene FlyBase D. melanogaster
FBgn0259174 CG42279 Nedd4 Nedd4 FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0033748 CG8821 vis vismay FlyBase D. melanogaster
FBgn0011763 CG4654 Dp DP transcription factor FlyBase D. melanogaster
FBgn0030735 CG3632 CG3632 FlyBase D. melanogaster
FBgn0011217 CG7425 eff effete FlyBase D. melanogaster
FBgn0015805 CG7471 Rpd3 Rpd3 FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0024371 CG1071 E2f2 E2F transcription factor 2 FlyBase D. melanogaster
FBgn0027052 CG5203 CHIP CHIP FlyBase D. melanogaster

85 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087053 A1Z916 Drosophila melanogaster
FBpp0087054 Q7JR08 Drosophila melanogaster
FBpp0305906 Q9VYK0 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0099512 Q5U110 Drosophila melanogaster
FBpp0086853 Q24318 Drosophila melanogaster
FBpp0081908 Q9VGI6 Drosophila melanogaster
FBpp0074968 O96433 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0085176 O62609 Drosophila melanogaster
FBpp0085177 Q8IMG6 Drosophila melanogaster
FBpp0085202 P55824 Drosophila melanogaster
FBpp0083320 Q9VDK5 Drosophila melanogaster
FBpp0087055 Q7K380 Drosophila melanogaster
FBpp0087056 A1Z913 Drosophila melanogaster
FBpp0071848 O17432 Drosophila melanogaster
FBpp0076098 Q9VT57 Drosophila melanogaster
FBpp0070141 Q24472 Drosophila melanogaster
FBpp0079617 Q9XYW6 Drosophila melanogaster
FBpp0082477 P25867 Drosophila melanogaster
FBpp0079278 Q9TVM2 Drosophila melanogaster
FBpp0082469 P25008 Drosophila melanogaster
FBpp0079030 Q8SXU2 Drosophila melanogaster
FBpp0079029 Q9VM47 Drosophila melanogaster
FBpp0086011 Q9V853 Drosophila melanogaster
FBpp0081029 O77051 Drosophila melanogaster
FBpp0071140 O96660 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0073173 Q94517 Drosophila melanogaster
FBpp0082667 Q9VF04 Drosophila melanogaster