modENCODE |  Help |  blog

Protein Domain : IPR020684

Name  Rho-associated protein kinase Short Name  Rho-assoc_coiled-coil_kin
Type  Family Description  Eukaryotic protein kinases [, , , ]are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.Rho kinases are serine/threonine kinases that are important in cell migration, cell proliferation and cell survival. Disorders of the central nervous system including stroke, inflammatory and demyelinating diseases, Alzheimer's disease and neuropathic pain may be linked to abnormal activation of Rho kinases [].This entry represents a set of Rho-associated, coiled-coil-containing, protein kinases. They phosphorylate a large number of important signalling proteins and help regulate the assembly of the actin cytoskeleton. Proteins in this entry have been shown to play a role in smooth muscle formation, and promote the formation of stress fibres and of focal adhesion complexes [, ].

Publication Counts Displayer

0 Child Features

10 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding Prot_Kinase_C-like_PE/DAG-bd Domain
IPR000961 AGC-kinase, C-terminal AGC-kinase_C Domain
IPR017892 Protein kinase, C-terminal Pkinase_C Domain
IPR015008 Rho binding domain Rho-bd_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF037568 PIRSF IPR020684

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rho-associated protein kinase   GO:0004674 protein serine/threonine kinase activity
Rho-associated protein kinase   GO:0006468 protein phosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rho-associated protein kinase   GO:0004674 protein serine/threonine kinase activity
Rho-associated protein kinase   GO:0006468 protein phosphorylation

0 Parent Features

3 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074061 Q9VXE3 Drosophila melanogaster
Q961D4_DROME Q961D4 Drosophila melanogaster
Q9U779_DROME Q9U779 Drosophila melanogaster