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Protein Domain : IPR011006

Name  CheY-like superfamily Short Name  CheY-like_superfamily
Type  Domain Description  CheY is a member of the response regulator family in bacterial two-component signalling systems, where CheY receives the signal from the sensor partner, usually a histidine protein kinase. Signal transduction involves phosphotransfer, whereby the histidine kinase phosphorylates a conserved aspartate in the response regulator to activate responses to environmental signals []. CheY is a single domain protein that folds into a compact globular unit with a flavodoxin-like fold consisting of three-layer alpha/beta/alpha sandwich with 21345 beta topology, where the phosphorylation region lies in a cavity.Other members of the response regulator family contain a CheY-like receiver domain, which is often found N-terminal to a DNA-binding effector domain. Examples include NarL (nitrate/nitrite response regulator), NtrC (nitrogen regulatory protein C), Spo0A and Spo0F (sporulation response) from Bacillus, PhoA and PhoB cyclin-dependent kinases from Aspergillus, among others.AmiR, the positive regulator of the amidase operon in Psuedomonas, is an unusual member of the bacterial response regulator family; AmiR is able to bind RNA and uses ligand-regulated activation rather than phopho-activation. It has a CheY-like fold at its N terminus, but contains two subdomains in a C-terminal extension, one forming a coiled-coil and the other a long alpha helix. As such AmiR may represent a new family of RNA-binding response regulators [].CheY-like domains can be found in other protein families as well. Examples include the receiver domain of the ethylene receptor (ETR1) from Arabidopsis, which is involved in ethylene detection and signal transduction []; the N-terminal wing' domain of ornithine decarboxylase from Lactobacilli, which catalyses the conversion of ornithine to putrescine at the beginning of the polyamine pathway []. The N-terminal domain of the circadian clock protein, KaiA, from cyanobacteria, acts as a psuedo-receiver domain, but lacks the conserved aspartyl residue required for phosphotransfer in responseregulators [].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR020844 Circadian clock protein KaiA, N-terminal Circadian_clock_KaiA_N Domain

3 Contains

DB identifier Name Short Name Type
IPR005308 Orn/Lys/Arg decarboxylase, N-terminal OKR_de-COase_N Domain
IPR005561 ANTAR domain ANTAR Domain
IPR010518 Flagellar regulatory FleQ FleQ Domain

1 Cross References

Source . Name

Subject . Primary Identifier
SSF52172 SSF IPR011006

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

4 Found In

DB identifier Name Short Name Type
IPR011193 Ornithine/lysine/arginine decarboxylase Orn/lys/arg_de-COase Family
IPR012074 GAF-ANTAR transcription anti-termination regulator, putative GAF_ANTAR Family
IPR011648 Circadian clock protein KaiA Circadian_clock_KaiA Family
IPR022305 Sortase system response regulator Response_regulator Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier Primary Accession
Organism . Name
H2X708_CAEJA H2X708 Caenorhabditis japonica
K7IGE0_CAEJA K7IGE0 Caenorhabditis japonica
E3NVS3_CAERE E3NVS3 Caenorhabditis remanei
E3NW83_CAERE E3NW83 Caenorhabditis remanei