modENCODE |  Help |  blog

Protein Domain : IPR003595

Name  Protein-tyrosine phosphatase, catalytic Short Name  Tyr_Pase_cat
Type  Domain Description  Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions.Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. This entry repesents the PTP-signature motif that characterises the catalytic site, and which encompasses only part of the PTPase domain structure.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR016130 Protein-tyrosine phosphatase, active site Tyr_Pase_AS Active_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SM00404 SMART IPR003595

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type Tyr_Pase_rcpt/non-rcpt Domain

8 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0257749 B4P9T1 Drosophila yakuba
K7HW14_CAEJA K7HW14 Caenorhabditis japonica
G0MCD7_CAEBE G0MCD7 Caenorhabditis brenneri
G0NZH6_CAEBE G0NZH6 Caenorhabditis brenneri
I2HAD7_CAEEL I2HAD7 Caenorhabditis elegans
Q9UAX0_CAEEL Q9UAX0 Caenorhabditis elegans
Q9TY27_CAEEL Q9TY27 Caenorhabditis elegans
F5GU90_CAEEL F5GU90 Caenorhabditis elegans