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Protein Domain : IPR016248

Name  Fibroblast growth factor receptor family Short Name  FGF_rcpt_fam
Type  Family Description  Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily.The FGFRs consist of an extracellular ligand-binding domain composed of three immunoglobulin-like domains (D1-D3), a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity []. The three immunoglobin(Ig)-like domains, D1, D2, and D3, present a stretch of acidic amino acids (knonw as the acid box) between D1 and D2. This acid box can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. FGFR family members differ from one another in their ligand affinities and tissue distribution [, ]. MostFGFs can bind to several different FGFR subtypes. Indeed, FGF1 is sometimes referred to as the universal ligand, as it is capable of activating all of the different FGFRs []. However, there are some exceptions. For example, FGF7 only interacts with FGFR2 []and FGF18 was recently shown to only activate FGFR3 []. This entry represents the fibroblast growth factor receptor family.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR028176 Fibroblast growth factor receptor 3 FGF_rcpt_3 Family
IPR028175 Fibroblast growth factor receptor 2 FGF_rcpt_2 Family
IPR028174 Fibroblast growth factor receptor 1/4 FGF_rcpt_1/4 Family

10 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000628 PIRSF IPR016248

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

6 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Fibroblast growth factor receptor family   GO:0005007 fibroblast growth factor-activated receptor activity
Fibroblast growth factor receptor family   GO:0005524 ATP binding
Fibroblast growth factor receptor family   GO:0006468 protein phosphorylation
Fibroblast growth factor receptor family   GO:0008284 positive regulation of cell proliferation
Fibroblast growth factor receptor family   GO:0008543 fibroblast growth factor receptor signaling pathway
Fibroblast growth factor receptor family   GO:0016021 integral component of membrane

6 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Fibroblast growth factor receptor family   GO:0005007 fibroblast growth factor-activated receptor activity
Fibroblast growth factor receptor family   GO:0005524 ATP binding
Fibroblast growth factor receptor family   GO:0006468 protein phosphorylation
Fibroblast growth factor receptor family   GO:0008284 positive regulation of cell proliferation
Fibroblast growth factor receptor family   GO:0008543 fibroblast growth factor receptor signaling pathway
Fibroblast growth factor receptor family   GO:0016021 integral component of membrane

0 Parent Features

5 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082971 Q07407 Drosophila melanogaster
FBpp0281059 Q293W0 Drosophila pseudoobscura
FBpp0301872 B5DX82 Drosophila pseudoobscura
FBpp0238391 B4LZ96 Drosophila virilis
FBpp0270249 B4PL61 Drosophila yakuba