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Protein Domain : IPR027139

Name  TNF receptor-associated factor 6 Short Name  TRAF6
Type  Family Description  TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10131:SF52 PANTHER IPR027139

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

15 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 6   GO:0004842 ubiquitin-protein transferase activity
TNF receptor-associated factor 6   GO:0004871 signal transducer activity
TNF receptor-associated factor 6   GO:0000209 protein polyubiquitination
TNF receptor-associated factor 6   GO:0001503 ossification
TNF receptor-associated factor 6   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 6   GO:0009887 organ morphogenesis
TNF receptor-associated factor 6   GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
TNF receptor-associated factor 6   GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
TNF receptor-associated factor 6   GO:0043507 positive regulation of JUN kinase activity
TNF receptor-associated factor 6   GO:0045672 positive regulation of osteoclast differentiation
TNF receptor-associated factor 6   GO:0046849 bone remodeling
TNF receptor-associated factor 6   GO:0048468 cell development
TNF receptor-associated factor 6   GO:0050852 T cell receptor signaling pathway
TNF receptor-associated factor 6   GO:0051865 protein autoubiquitination
TNF receptor-associated factor 6   GO:0070498 interleukin-1-mediated signaling pathway

15 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 6   GO:0004842 ubiquitin-protein transferase activity
TNF receptor-associated factor 6   GO:0004871 signal transducer activity
TNF receptor-associated factor 6   GO:0000209 protein polyubiquitination
TNF receptor-associated factor 6   GO:0001503 ossification
TNF receptor-associated factor 6   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 6   GO:0009887 organ morphogenesis
TNF receptor-associated factor 6   GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
TNF receptor-associated factor 6   GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
TNF receptor-associated factor 6   GO:0043507 positive regulation of JUN kinase activity
TNF receptor-associated factor 6   GO:0045672 positive regulation of osteoclast differentiation
TNF receptor-associated factor 6   GO:0046849 bone remodeling
TNF receptor-associated factor 6   GO:0048468 cell development
TNF receptor-associated factor 6   GO:0050852 T cell receptor signaling pathway
TNF receptor-associated factor 6   GO:0051865 protein autoubiquitination
TNF receptor-associated factor 6   GO:0070498 interleukin-1-mediated signaling pathway

1 Parent Features

DB identifier Name Short Name Type
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0071136 Q9W3I9 Drosophila melanogaster
FBpp0282681 Q29HD1 Drosophila pseudoobscura
FBpp0163627 B4L8G7 Drosophila mojavensis
FBpp0233175 B4M202 Drosophila virilis
FBpp0262485 B4Q0E8 Drosophila yakuba
Q9UAC4_DROME Q9UAC4 Drosophila melanogaster
Q9XYQ9_DROME Q9XYQ9 Drosophila melanogaster