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Protein Domain : IPR027139

Name	TNF receptor-associated factor 6	Short Name	TRAF6
Type	Family	Description	TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PTHR10131:SF52	PANTHER	IPR027139

3 Data Sets

Name	URL
TrEMBL data set	http://www.ebi.ac.uk/trembl/
InterPro data set
InterPro GO Annotation data set

0 Found In

15 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	TNF receptor-associated factor 6		GO:0004842	ubiquitin-protein transferase activity
	TNF receptor-associated factor 6		GO:0004871	signal transducer activity
	TNF receptor-associated factor 6		GO:0000209	protein polyubiquitination
	TNF receptor-associated factor 6		GO:0001503	ossification
	TNF receptor-associated factor 6		GO:0007250	activation of NF-kappaB-inducing kinase activity
	TNF receptor-associated factor 6		GO:0009887	organ morphogenesis
	TNF receptor-associated factor 6		GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
	TNF receptor-associated factor 6		GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
	TNF receptor-associated factor 6		GO:0043507	positive regulation of JUN kinase activity
	TNF receptor-associated factor 6		GO:0045672	positive regulation of osteoclast differentiation
	TNF receptor-associated factor 6		GO:0046849	bone remodeling
	TNF receptor-associated factor 6		GO:0048468	cell development
	TNF receptor-associated factor 6		GO:0050852	T cell receptor signaling pathway
	TNF receptor-associated factor 6		GO:0051865	protein autoubiquitination
	TNF receptor-associated factor 6		GO:0070498	interleukin-1-mediated signaling pathway

15 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	TNF receptor-associated factor 6		GO:0004842	ubiquitin-protein transferase activity
	TNF receptor-associated factor 6		GO:0004871	signal transducer activity
	TNF receptor-associated factor 6		GO:0000209	protein polyubiquitination
	TNF receptor-associated factor 6		GO:0001503	ossification
	TNF receptor-associated factor 6		GO:0007250	activation of NF-kappaB-inducing kinase activity
	TNF receptor-associated factor 6		GO:0009887	organ morphogenesis
	TNF receptor-associated factor 6		GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
	TNF receptor-associated factor 6		GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
	TNF receptor-associated factor 6		GO:0043507	positive regulation of JUN kinase activity
	TNF receptor-associated factor 6		GO:0045672	positive regulation of osteoclast differentiation
	TNF receptor-associated factor 6		GO:0046849	bone remodeling
	TNF receptor-associated factor 6		GO:0048468	cell development
	TNF receptor-associated factor 6		GO:0050852	T cell receptor signaling pathway
	TNF receptor-associated factor 6		GO:0051865	protein autoubiquitination
	TNF receptor-associated factor 6		GO:0070498	interleukin-1-mediated signaling pathway

1 Parent Features

DB identifier	Name	Short Name	Type
IPR012227	TNF receptor-associated factor TRAF	TNF_rcpt--assoc_TRAF	Family

7 Proteins

DB identifier	Primary Accession	Organism . Name
FBpp0071136	Q9W3I9	Drosophila melanogaster
FBpp0282681	Q29HD1	Drosophila pseudoobscura
FBpp0163627	B4L8G7	Drosophila mojavensis
FBpp0233175	B4M202	Drosophila virilis
FBpp0262485	B4Q0E8	Drosophila yakuba
Q9UAC4_DROME	Q9UAC4	Drosophila melanogaster
Q9XYQ9_DROME	Q9XYQ9	Drosophila melanogaster

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