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Protein Domain : IPR001789

Name  Signal transduction response regulator, receiver domain Short Name  Sig_transdc_resp-reg_receiver
Type  Domain Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].Bipartite response regulator proteins are involved in a two-component signal transduction system in bacteria, and certain eukaryotes like protozoa, that functions to detect and respond to environmental changes []. These systems have been detected during host invasion, drug resistance, motility, phosphate uptake, osmoregulation, and nitrogen fixation, amongst others []. The two-component system consists of a histidine protein kinase environmental sensor that phosphorylates the receiver domain of a response regulator protein; phosphorylation induces a conformational change in the response regulator, which activates the effector domain, triggering the cellular response []. The domains of the two-component proteins are highly modular, but the core structures and activities are maintained.The response regulators act as phosphorylation-activated switches to affect a cellular response, usually by transcriptional regulation. Most of these proteins consist of two domains, an N-terminal response regulator receiver domain, and a variable C-terminal effector domain with DNA-binding activity. This entry represents the response regulator receiver domain, which belongs to the CheY family, and receives the signal from the sensor partner in the two-component system.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00072 PFAM IPR001789
PS50110 PROFILE IPR001789
SM00448 SMART IPR001789

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

20 Found In

DB identifier Name Short Name Type
IPR009219 Bacteriophytochrome, CheY-like Bactrphtchr_CheY Family
IPR010114 Signal transduction response regulator, nitrogen regulation NR(I) Sig_transdc_resp-reg_NtrC Family
IPR014264 Signal transduction response regulator, PEP-CTERM system, putative Sig_transdc_resp-reg_PEP-CTERM Family
IPR014525 Signal transduction histidine kinase, hybrid-type, ethylene sensor Sig_transdc_His_kin_hyb_Et-sen Family
IPR014626 Signal transduction response regulator, modified HD-GYP domain-containing, putative Sig_transdc_resp-reg_put Family
IPR022305 Sortase system response regulator Response_regulator Family
IPR014402 Transcription factor, Skn7-like Sig_transdc_resp-reg_Skn7 Family
IPR017053 Response regulator, plant B-type Response_reg_B-typ_pln Family
IPR014409 Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB Sig_transdc_His_kin_hyb_ArcB Family
IPR011879 Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB Sig_transdc_resp-reg_PhoB Family
IPR006291 Signal transduction response regulator, heavy metal response Sig_transdc_resp-reg_metal Family
IPR017206 Signal transduction histidine kinase, hybrid-type, BC3207, predicted Sig_transdc_His_kin_hyb_BC3207 Family
IPR014460 Signal transduction response regulator, predicted, VieB Sig_transdc_resp-reg_VieB Family
IPR014302 Signal transduction histidine kinase, TMAO sensor TorS Sig_transdc_His_kinase_TorS Family
IPR008327 Signal transduction response regulator, antiterminator Sig_transdc_resp-reg_antiterm Family
IPR016837 Uncharacterised protein family Ycf55, cyanobacteria Uncharacterised_Ycf55_cyanobac Family
IPR012052 Sporulation transcription factor Spo0A Spore_0_A Family
IPR008248 Signal transduction response regulator, chemotaxis, CheB Sig_transdc_resp-reg_CheB Family
IPR014605 Signal transduction response regulator, PhyR-like, C-terminal, alphaproteobacteria Sig_transdc_resp-reg_PhyR_C Domain
IPR014483 Fis-like DNA-binding domain-containing signal transduction response regulator, predicted Sig_transdc_resp-reg_prd Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, receiver domain   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, receiver domain   GO:0000160 phosphorelay signal transduction system

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, receiver domain   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, receiver domain   GO:0000160 phosphorelay signal transduction system

1 Parent Features

DB identifier Name Short Name Type
IPR011006 CheY-like superfamily CheY-like_superfamily Domain

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0310594 Q6NNF2 Drosophila melanogaster
FBpp0310591 Q8MLR0 Drosophila melanogaster
FBpp0310589 Q8MLR1 Drosophila melanogaster
FBpp0310590 Q9W1L9 Drosophila melanogaster
FBpp0308134 N6W5V0 Drosophila pseudoobscura
FBpp0308133 Q28ZF2 Drosophila pseudoobscura
FBpp0168245 B4KS04 Drosophila mojavensis
FBpp0234411 B4LLX8 Drosophila virilis
FBpp0259321 B4P9Q8 Drosophila yakuba
H2X708_CAEJA H2X708 Caenorhabditis japonica
K7IGE0_CAEJA K7IGE0 Caenorhabditis japonica
Q8IGT9_DROME Q8IGT9 Drosophila melanogaster
E3NVS3_CAERE E3NVS3 Caenorhabditis remanei
E3NW83_CAERE E3NW83 Caenorhabditis remanei