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Protein Domain : IPR027138

Name  TNF receptor-associated factor 4 Short Name  TRAF4
Type  Family Description  TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [, , , , , ]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10131:SF71 PANTHER IPR027138

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 4   GO:0007165 signal transduction
TNF receptor-associated factor 4   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 4   GO:0046330 positive regulation of JNK cascade

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TNF receptor-associated factor 4   GO:0007165 signal transduction
TNF receptor-associated factor 4   GO:0007250 activation of NF-kappaB-inducing kinase activity
TNF receptor-associated factor 4   GO:0046330 positive regulation of JNK cascade

1 Parent Features

DB identifier Name Short Name Type
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0077119 Q9XYR0 Drosophila melanogaster
FBpp0306504 A8DYU9 Drosophila melanogaster
FBpp0279527 Q29LI9 Drosophila pseudoobscura
FBpp0171257 B4KES9 Drosophila mojavensis
FBpp0230538 B4MDS3 Drosophila virilis
FBpp0263293 B4NYJ2 Drosophila yakuba
Q9UAC5_DROME Q9UAC5 Drosophila melanogaster