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Protein Domain : IPR024804

Name  G-protein-signalling modulator 1 Short Name  G_prot_signal_mod_1
Type  Family Description  The heterotrimeric G protein is composed of three subunits - alpha, beta and gamma - and is functionally linked to a G-protein coupled receptor (GPCR). The alpha subunit is a GTPase that alternates between GDP-bound (inactive) and GTP-bound (active) states. The beta and gamma subunits form a heterodimer, known as the beta-gamma complex, that binds with high affinity to GDP-bound alpha subunit, slowing its release of GDP and facilitating its coupling to the receptor. Binding of the GPCR to its cognate signal promotes the release of GDP from the alpha subunit, causing it to bind ATP and dissociate from the beta-gamma complex. Both the GTP-bound alpha subunit and the free beta-gamma complex can then inititate sigalling by interacting with downstream proteins. The GTPase activity of the alpha subunit leads to the GDP-bound state, reassociation with the beta-gamma complex, and the termination of signalling. Two classes of proteins have been identified that can inhibit GPCR-linked signalling by interfering with alpha subunit activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation [, ,].G-protein-signalling modulator 1 (also known as Ags3) is a GDI that is involved in cell polarity and cell cycle progression [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10098:SF36 PANTHER IPR024804

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
G-protein-signalling modulator 1   GO:0005092 GDP-dissociation inhibitor activity
G-protein-signalling modulator 1   GO:0008277 regulation of G-protein coupled receptor protein signaling pathway

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
G-protein-signalling modulator 1   GO:0005092 GDP-dissociation inhibitor activity
G-protein-signalling modulator 1   GO:0008277 regulation of G-protein coupled receptor protein signaling pathway

0 Parent Features

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084559 Q9VB22 Drosophila melanogaster
FBpp0283297 Q29BH6 Drosophila pseudoobscura
FBpp0171228 B4KBA4 Drosophila mojavensis
FBpp0224880 B4M633 Drosophila virilis
FBpp0268756 B4PRC7 Drosophila yakuba
Q9NH88_DROME Q9NH88 Drosophila melanogaster
Q9NFR7_DROME Q9NFR7 Drosophila melanogaster