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Protein Domain : IPR001562

Name  Zinc finger, Btk motif Short Name  Znf_Btk_motif
Type  Conserved_site Description  The Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice [, ]. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain () and the Src homology 3 (SH3) domain (). The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins [, ]. The TH domain may be of functional importance in various signalling pathways in different species []. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain []. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif []. Proteins known to contain a Btk-type zinc finger include:Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival. Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00779 PFAM IPR001562
PR00402 PRINTS IPR001562
PS51113 PROFILE IPR001562
SM00107 SMART IPR001562
G3DSA:4.10.1130.10 GENE3D IPR001562

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, Btk motif   GO:0035556 intracellular signal transduction

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, Btk motif   GO:0035556 intracellular signal transduction

0 Parent Features

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076096 P48423 Drosophila melanogaster
FBpp0303201 M9PF62 Drosophila melanogaster
FBpp0079236 P08630 Drosophila melanogaster
FBpp0288262 Q29F43 Drosophila pseudoobscura
FBpp0280509 Q29MM7 Drosophila pseudoobscura
FBpp0163039 B4KVN5 Drosophila mojavensis
FBpp0163461 B4KJM3 Drosophila mojavensis
FBpp0226105 B4LEV9 Drosophila virilis
FBpp0234998 B4LSH1 Drosophila virilis
FBpp0256084 B4NWV3 Drosophila yakuba
FBpp0265306 B4PDX2 Drosophila yakuba
BTKL_DROME-2 P08630-2 Drosophila melanogaster