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Protein Domain : IPR015009

Name  Vinculin-binding site-containing domain Short Name  Vinculin-bd_dom
Type  Domain Description  Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PF08913 PFAM IPR015009

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR015710 Talin-1 Talin-1 Family
IPR015711 Talin-2 Talin-2 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

17 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293740 Q9VSL8 Drosophila melanogaster
FBpp0293741 M9NDM3 Drosophila melanogaster
FBpp0305319 M9PBW9 Drosophila melanogaster
FBpp0305320 M9PEJ8 Drosophila melanogaster
FBpp0277245 Q29FI8 Drosophila pseudoobscura
FBpp0162125 B4KZ53 Drosophila mojavensis
FBpp0227466 B4LEJ9 Drosophila virilis
FBpp0265762 B4PG07 Drosophila yakuba
B6IM09_CAEBR B6IM09 Caenorhabditis briggsae
K7H706_CAEJA K7H706 Caenorhabditis japonica
K7H707_CAEJA K7H707 Caenorhabditis japonica
G0MNX3_CAEBE G0MNX3 Caenorhabditis brenneri
G5EGK1_CAEEL G5EGK1 Caenorhabditis elegans
W6SBK6_CAEEL W6SBK6 Caenorhabditis elegans
G4S9F5_CAEEL G4S9F5 Caenorhabditis elegans
Q960C2_DROME Q960C2 Drosophila melanogaster
E3LXS8_CAERE E3LXS8 Caenorhabditis remanei