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Protein Domain : IPR000289

Name  Ribosomal protein S28e Short Name  Ribosomal_S28e
Type  Family Description  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. Examples are:Mammalian S28 []Plant S28 []Fungi S33 []Archaebacterial S28e.These proteins have from 64 to 78 amino acids and a highly conserved C-terminal region.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR012340 Nucleic acid-binding, OB-fold NA-bd_OB-fold Domain

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10769 PANTHER IPR000289
PF01200 PFAM IPR000289
PD005541 PRODOM IPR000289
MF_00292 HAMAP IPR000289

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S28e   GO:0003735 structural constituent of ribosome
Ribosomal protein S28e   GO:0006412 translation
Ribosomal protein S28e   GO:0005622 intracellular
Ribosomal protein S28e   GO:0005840 ribosome

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ribosomal protein S28e   GO:0003735 structural constituent of ribosome
Ribosomal protein S28e   GO:0006412 translation
Ribosomal protein S28e   GO:0005622 intracellular
Ribosomal protein S28e   GO:0005840 ribosome

0 Parent Features

16 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084966 Q9VAB9 Drosophila melanogaster
FBpp0071295 Q9W334 Drosophila melanogaster
FBpp0111290 A8DYY3 Drosophila melanogaster
FBpp0272676 Q29ID4 Drosophila pseudoobscura
FBpp0279709 B5DH72 Drosophila pseudoobscura
FBpp0163595 B4L8F0 Drosophila mojavensis
FBpp0166857 B4KI73 Drosophila mojavensis
FBpp0232622 B4M8X7 Drosophila virilis
FBpp0263852 B4NY38 Drosophila yakuba
FBpp0268434 B4PLQ8 Drosophila yakuba
A8XI84_CAEBR A8XI84 Caenorhabditis briggsae
B4M221_DROVI B4M221 Drosophila virilis
G0N6K2_CAEBE G0N6K2 Caenorhabditis brenneri
RS28_CAEEL Q95Y04 Caenorhabditis elegans
B4PWX1_DROYA B4PWX1 Drosophila yakuba
E3NBQ7_CAERE E3NBQ7 Caenorhabditis remanei