modENCODE |  Help |  blog

Protein Domain : IPR015212

Name  Regulator of G protein signalling-like domain Short Name  RGS-like_dom
Type  Domain Description  This entry represents a domain consisting of twelve helices that fold into a compact structure that contains the overall structural scaffold observed in other regulator of G protein signalling (RGS) proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. This domain binds to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways []. This RGS-like domain is found in Rho guanine nucleotide exchange factors (RhoGEF) such as Pdz-RhoGEF []and p115RhoGEF [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF09128 PFAM IPR015212

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR015721 Rho GTP exchange factor RhoGEF-like Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Regulator of G protein signalling-like domain   GO:0005089 Rho guanyl-nucleotide exchange factor activity
Regulator of G protein signalling-like domain   GO:0005737 cytoplasm

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Regulator of G protein signalling-like domain   GO:0005089 Rho guanyl-nucleotide exchange factor activity
Regulator of G protein signalling-like domain   GO:0005737 cytoplasm

1 Parent Features

DB identifier Name Short Name Type
IPR016137 Regulator of G protein signalling superfamily Regulat_G_prot_signal_superfam Domain

17 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0276614 B5E0Q5 Drosophila pseudoobscura
FBpp0170556 B4KML9 Drosophila mojavensis
FBpp0234102 B4MCK8 Drosophila virilis
FBpp0256648 B4P8I4 Drosophila yakuba
A8WXP4_CAEBR A8WXP4 Caenorhabditis briggsae
B6IKF7_CAEBR B6IKF7 Caenorhabditis briggsae
H2W7J5_CAEJA H2W7J5 Caenorhabditis japonica
G0MI70_CAEBE G0MI70 Caenorhabditis brenneri
G5EFE1_CAEEL G5EFE1 Caenorhabditis elegans
Q6T5A2_CAEEL Q6T5A2 Caenorhabditis elegans
Q8T9E3_DROME Q8T9E3 Drosophila melanogaster
E8NH10_DROME E8NH10 Drosophila melanogaster
O44113_DROME O44113 Drosophila melanogaster
O44381_DROME O44381 Drosophila melanogaster
E3M234_CAERE E3M234 Caenorhabditis remanei