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Protein Domain : IPR016279

Name  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma Short Name  PLC-gamma
Type  Family Description  This group represents a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma. Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.

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2 Child Features

DB identifier Name Short Name Type
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLC-gamma2 Family
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLC-gamma1 Family

10 Contains

DB identifier Name Short Name Type
IPR000008 C2 domain C2_dom Domain
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR000980 SH2 domain SH2 Domain
IPR001452 SH3 domain SH3_domain Domain
IPR018247 EF-Hand 1, calcium-binding site EF_Hand_1_Ca_BS Binding_site
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain PLC-like_Pdiesterase_TIM-brl Domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like PLipase_C_EF-hand-like Domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain PLipase_C_PInositol-sp_X_dom Domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain PLipase_C_Pinositol-sp_Y Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000952 PIRSF IPR016279

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0004435 phosphatidylinositol phospholipase C activity
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0004871 signal transducer activity
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0007165 signal transduction
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0009395 phospholipid catabolic process

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0004435 phosphatidylinositol phospholipase C activity
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0004871 signal transducer activity
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0007165 signal transduction
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma   GO:0009395 phospholipid catabolic process

1 Parent Features

DB identifier Name Short Name Type
IPR001192 Phosphoinositide phospholipase C family PI-PLC_fam Family

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074009 Q9VXH3 Drosophila melanogaster
FBpp0274154 B5DNH4 Drosophila pseudoobscura
FBpp0163674 B4L8R0 Drosophila mojavensis
FBpp0233208 Q86RA6 Drosophila virilis
FBpp0262274 B4PXS1 Drosophila yakuba
A8XTZ1_CAEBR A8XTZ1 Caenorhabditis briggsae
H2VYJ9_CAEJA H2VYJ9 Caenorhabditis japonica
G0PIK1_CAEBE G0PIK1 Caenorhabditis brenneri
G0N3X3_CAEBE G0N3X3 Caenorhabditis brenneri
Q22070_CAEEL Q22070 Caenorhabditis elegans
Q24284_DROME Q24284 Drosophila melanogaster
E3MQ20_CAERE E3MQ20 Caenorhabditis remanei
Q86RA5_DROPS Q86RA5 Drosophila pseudoobscura